Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection

Liao, Zerong; Wang, Jianfeng; Zhang, Pengjie; Zhang, Yang; Miao, Yunfei; Gao, Shimeng; Deng, Yulin; Li, Geng

doi:10.1016/j.bios.2018.08.061

Cited by 92 publications

(61 citation statements)

References 91 publications

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“…Compared with OECTs with metal gate electrodes, all-polymer OECTs offer many advantages, such as low cost, easy fabrication, and compatible with a flexible substrate. Besides, all-PEDOT:PSS OECTs facilitate the integration with microfluidic channels for point-of-care testing (POCT) applications [10,61,62,63,64]. As shown in Figure 6a, a “finger-powered” (poly(dimethylsiloxane)) PDMS microfluidic OECT platform was constructed on a glass substrate [62].…”

Section: Gate Surface As Sensing Interfacementioning

confidence: 99%

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Liao

Zhang

et al. 2019

Sensors

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Organic electrochemical transistors (OECTs) are promising devices for applications in in vitro and in vivo measurements. OECTs have two important sensing interfaces for signal monitoring: One is the gate electrode surface; the other is the channel surface. This mini review introduced the new developments in chemical and biological detection of the two sensing interfaces. Specific focus was given on the modification technological approaches of the gate or channel surface. In particular, some unique strategies and surface designs aiming to facilitate signal-transduction and amplification were discussed. Several perspectives and current challenges of OECTs development were also briefly summarized.

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Section: Gate Surface As Sensing Interfacementioning

confidence: 99%

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Liao

Zhang

et al. 2019

Sensors

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“…A challenge in the future is the integration of relevant key enabling technologies on an industrial scale (microfluidics with microelectronics, highly sensitive detection methods and low-cost materials for easy-to-use tools) [147][148][149][150] with biological components like S-layer proteins [7,10]. In general, biomolecules with self-assembly capability will play a pivotal role.…”

Section: Discussionmentioning

confidence: 99%

Electrochemical Biosensors Based on S-Layer Proteins

Damiati

Schuster

2020

Sensors

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Designing and development of electrochemical biosensors enable molecule sensing and quantification of biochemical compositions with multitudinous benefits such as monitoring, detection, and feedback for medical and biotechnological applications. Integrating bioinspired materials and electrochemical techniques promote specific, rapid, sensitive, and inexpensive biosensing platforms for (e.g., point-of-care testing). The selection of biomaterials to decorate a biosensor surface is a critical issue as it strongly affects selectivity and sensitivity. In this context, smart biomaterials with the intrinsic self-assemble capability like bacterial surface (S-) layer proteins are of paramount importance. Indeed, by forming a crystalline two-dimensional protein lattice on many sensors surfaces and interfaces, the S-layer lattice constitutes an immobilization matrix for small biomolecules and lipid membranes and a patterning structure with unsurpassed spatial distribution for sensing elements and bioreceptors. This review aims to highlight on exploiting S-layer proteins in biosensor technology for various applications ranging from detection of metal ions over small organic compounds to cells. Furthermore, enzymes immobilized on the S-layer proteins allow specific detection of several vital biomolecules. The special features of the S-layer protein lattice as part of the sensor architecture enhances surface functionalization and thus may feature an innovative class of electrochemical biosensors.

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“…The chemistries of zinc and cadmium are similar; however, that of mercury is vastly different. All three elements are found in the +2 oxidation state, they all adopt a range of coordination numbers (2,4, and 6 being the most common) and form tetrahedral and octahedral complexes [71]. Mercury is found predominantly in a linear (coordination 2) or tetrahedral (coordination 4) geometry [72,73].…”

Section: Chemosensors For the Group 12 Triad (Zinc Cadmium And Mercmentioning

confidence: 99%

“…Both types of sensors have the same purpose; to measure an analyte, either qualitatively or quantitatively. Some excellent reviews have covered recent advances in biosensors, and these have been omitted in this article [2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Low Molecular Weight Fluorescent Probes (LMFPs) to Detect the Group 12 Metal Triad

2019

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Fluorescence sensing, of d-block elements such as Cu2+, Fe3+, Fe2+, Cd2+, Hg2+, and Zn2+ has significantly increased since the beginning of the 21st century. These particular metal ions play essential roles in biological, industrial, and environmental applications, therefore, there has been a drive to measure, detect, and remediate these metal ions. We have chosen to highlight the low molecular weight fluorescent probes (LMFPs) that undergo an optical response upon coordination with the group 12 triad (Zn2+, Cd2+, and Hg2+), as these metals have similar chemical characteristics but behave differently in the environment.

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Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection

Cited by 92 publications

References 91 publications

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Electrochemical Biosensors Based on S-Layer Proteins

Low Molecular Weight Fluorescent Probes (LMFPs) to Detect the Group 12 Metal Triad

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