Recent advances in microbial toxin-related strategies to combat cancer

Sharma, Prabodh Chander; Sharma, Diksha; Sharma, Archana; Bhagat, Madhulika; Ola, Monika; Thakur, Vijay Kumar; Bhardwaj, Jitender Kumar; Goyal, Ramesh K.

doi:10.1016/j.semcancer.2021.07.007

Cited by 35 publications

(32 citation statements)

References 146 publications

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“…Although there has been progress in cancer research to reduce mortality and improve the survival rate, cancer still accounts for nearly one in every six deaths and is the second leading cause of death worldwide [1]. There have been numerous approaches such as chemotherapy, radiotherapy and surgery to prevent and treat cancer, and some signs of progress have been made, but the need to develop pioneering, effective treatments for cancer still exists [3,4]. The prevalence of side effects and adverse drug reactions is the problem associated with existing cancer treatments [5].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

et al. 2021

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Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various developments to prevent and treat cancer, the side effects of anticancer drugs remain a major concern. Ascorbic acid is an essential vitamin required by our bodies for normal physiological function and also has antioxidant and anticancer activity. Although the body cannot synthesize ascorbic acid, it is abundant in nature through foods and other natural sources and also exists as a nutritional food supplement. In anticancer drug development, ascorbic acid has played an important role by inhibiting the development of cancer through various mechanisms, including scavenging reactive oxygen species (ROS), selectively producing ROS and encouraging their cytotoxicity against tumour cells, preventing glucose metabolism, serving as an epigenetic regulator, and regulating the expression of HIF in tumour cells. Several ascorbic acid analogues have been produced to date for their anticancer and antioxidant activity. The current review summarizes the mechanisms behind ascorbic acid's antitumor activity, presents a compilation of its derivatives and their biological activity as anticancer agents, and discusses delivery systems such as liposomes, nanoparticles against cancer, and patents on ascorbic acid as anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

et al. 2021

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“…This was consistent with a previously published study ( Coker et al, 2019 ). Aspergillus flavus was reported to be involved in the production of aflatoxin , targeting aryl hydrocarbon receptor to mediate the expression of P450 to induce hepatocellular carcinoma process, indicating that these species seemed to have an underestimated relation with colorectal cancer ( Sharma et al, 2021 ; Zhu et al, 2021a ). Debaryomyces fabryi was also significantly enriched in CRC.…”

Section: Discussionmentioning

confidence: 99%

Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer

Gao

Xia

et al. 2022

Front. Cell. Infect. Microbiol.

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Accumulating evidence indicates that gut microbiota dysbiosis contributes to colorectal cancer and adenoma. However, a few studies revealed the altered gut mycobiota architecture in colorectal cancer. The present study characterized the gut mycobiota profiles in adenoma and colorectal cancer patients by metagenomic sequencing. Malassezia restricta increased, while Leucoagaricus_sp_SymCcos and fungal_sp_ARF18 significantly decreased in adenoma. Phanerochaete_chrysosporium, Lachancea_waltii, and Aspergillus_rambellii were the top 3 fungi that were significantly enriched in colorectal cancer, while Candida_versatilis, Pseudocercospora_pini_densiflorae, and Candida_sp_JCM_15000 were dominant in the healthy controls. Thirteen fungi, ranked as critical biomarkers in diagnosing colorectal cancer, showed positive associations among all samples. Lachancea_waltii and Phanerochaete_chrysosporium showed the most significant association within CRC. The values of area under the receiver-operating characteristics curve (AUROC) of selected 13 mycobiota were 0.926 in the training model and 0.757 in the 10-fold validation model. Our study provided a reliable investigation of the alterations of gut mycobiota in the development of colorectal cancer and established a convincing diagnostic model for colorectal cancer, which might improve the treatment strategy for colorectal cancer in the future.

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“…Furthermore, C. novyi spores have been investigated in combination with radiotherapy, radioimmunotherapy, and other chemotherapy in experimental tumor models [ 54 ]. Bacterial toxins are another effective means of inhibiting the growth of cancer cells ( Figure 1 ) [ 71 ]. Bacterial toxins with antitumor activity are presented in detail in the next section.…”

Section: Molecular Mechanisms Of Anticancer Bacterial Actionmentioning

confidence: 99%

Fighting Cancer with Bacteria and Their Toxins

Trivanović

Pavelić

Peršurić

2021

IJMS

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Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents.

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Recent advances in microbial toxin-related strategies to combat cancer

Cited by 35 publications

References 146 publications

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer

Fighting Cancer with Bacteria and Their Toxins

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