Recent Advances in Metal Organic Frameworks Based Surface Enhanced Raman Scattering Substrates: Synthesis and Applications

Abstract

Metal-organic frameworks (MOFs) are supramolecular nanomaterials, in which metal ions or clusters are connected by organic ligands to form crystalline lattices with highly ordered periodic porous network structure. MOFs have been widely applied in various fields, such as catalyst, sample preparation, and sensing. In recent years, MOFs based surface enhanced Raman scattering (SERS) substrates have attracted much attention since MOFs can largely improve the performance of metallic SERS substrates toward target enrichment and signal enhancement. MOFs have been exploited in SERS analysis to tackle some challenges that bare metal substrates cannot achieve. Combination of MOFs and SERS improved the sensitivity of traditional SERS analysis and extended the application scope of SERS. With the increasing exploration of MOFs based SERS substrates, there is a great demand to review the advances in these researches. Herein, this review concentrated on summarizing the preparation and applications of MOFs based SERS substrates. Representative researches were discussed to better understand the property of MOFs based SERS substrates. The advantages of MOFs based SERS substrates were highlighted, as well as their limitations. In addition, the challenges, opportunities, and future trends in MOFs based SERS analysis were tentatively discussed.

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

“…[ 120 ] Due to its many advantages such as ultrahigh sensitivity, fingerprint identification, and in situ noninvasive detection, SERS has evolved to become a powerful analytical technology. [ 135 ] Recently, nanozyme‐based cascade nanoreactors have been used to develop SERS biosensors. Using the in situ growth of AuNPs into a MOF (MIL‐101) with porosity and thermal stability, the group of Wei developed a POD‐mimicking AuNPs@MIL‐101 nanozyme, which could catalyze the oxidation of leucomalachite green (Raman‐inactive reporter) to form the active malachite green (MG) in the presence of H 2 O 2 and in addition served as the SERS substrate for enhancing the MG Raman signal.…”

CRISPR/Cas Systems‐Inspired Nano/Biosensors for Detecting Infectious Viruses and Pathogenic Bacteria

“…[98,[172][173][174][175] In addition, some nanomaterials have been used as promising and sensitive SERS substrates to improve the detection performances of SERS biosensing. [176,177] Remarkably, based on the synergistic combination of the superior sensitivity of SERS, the specific recognition capability of CRISPR/ Cas system with easy separation and SERS hot spot properties of Au-coated magnetic nanoparticles (abbreviated as Au MNPs), Kim et al for the first time developed a novel CRISPR/Cas system-mediated SERS biosensing platform for the accurate detection of multidrug-resistant (MDR) bacteria pathogens (i.e., Klebsiella pneumoniae, Acinetobacter baumannii, and S. aureus) without any complex purification/amplification procedures (Figure 5A). To establish this platform, the MDR bacteria pathogens were recognized by the designed dCas9/gRNA ribonucleoproteins (RNPs), and the dCas9/gRNA RNPs were immobilized onto the Au MNPs.…”

Synthesis of coordination polymers based on a 2,2′-dimethoxy-1,1′-biphenyl scaffold and Hg(II), Co(II), or Zn(II)

“…Thereby, several coordination polymers have been synthesized. However, to obtain CPs with desirable properties and reactivity, appropriate organic ligands and metal ions must be judiciously selected [21][22][23].…”