Recent Advances in Metal‐ and Organocatalyzed Asymmetric Functionalization of Pyrroles

Abstract

The wide occurrence of pyrroles in natural products and pharmaceuticals calls for novel synthetic methodologies for the efficient synthesis of enantiopure pyrroles. Owing to their highly reactive nature and wide-ranging chemical landscape, enormous efforts have been dedicated not only to their synthesis but also to the development of reactions using them as a platform and their utilization in the stereocontrolled synthesis of diverse molecules. In sharp contrast to the extensive studies devoted toward indoles, the asymmetric functionalization of pyrroles was less explored. Never-theless, the attractiveness of pyrroles for their selective functionalization to access natural product analogy, and medicinally useful architectures have witnessed tremendous growth in the last few years. Their effectiveness under both metal-and organocatalytic conditions currently encompasses a vast majority of enantioselective transformations. This review article aims to present a comprehensive overview of the catalytic asymmetric CÀ H as well as NÀ H functionalization of pyrroles reported from 2010 to now.

Valorization of Spent Coffee Grounds as a Natural Source of Bioactive Compounds for Several Industrial Applications—A Volatilomic Approach

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