Recent Advances in Mass Spectrometry for the Identification of Neurochemicals and their Metabolites in Biofluids

Abstract

Recently, mass spectrometric related techniques have been widely applied for the identification and quantification of neurochemicals and their metabolites in biofluids. This article presents an overview of mass spectrometric techniques applied in the detection of neurological substances and their metabolites from biological samples. In addition, the advances of chromatographic methods (LC, GC and CE) coupled with mass spectrometric techniques for analysis of neurochemicals in pharmaceutical and biological samples are also discussed.

Racemic drug resolution: a comprehensive guide

“…In ID, LCMS/MS and GCMS/MS are potentially used for the enantioseparation of drug molecules, 195 biological uids, 196 and for the determination of acids in a plasma. 197 Kailasa et al 198 have discussed the application of mass spectrometry (ID) in the detection of neurochemicals and their metabolites in biouids.…”

Serbest Duran ve Esnek MnO2/Grafen Kağıt Elektrot: Dopamin Tayini İçin Yeni Tip Amperometrik Sensör

“…DA tayini için, kemilüminesans (Lan vd., 2019), floresans (Wang ve He, 2017), kolorimetri (Wen vd., 2016), UV-spektroskopisi (El-Dien vd., 2005), yüzeyle geliştirilmiş Raman saçılması (SERS) (Zhang vd., 2018), yüksek performanslı sıvı kromatografisi (HPLC) ( De Benedetto vd., 2014) ve kütle spektroskopisi gibi (Kailasa ve Wu, 2013) çeşitli yöntemler kullanılmaktadır. Bu teknikler hassas olmasına rağmen, pahalı, karmaşık ve zaman alıcıdır.…”