Recent advances in magnetic nanoparticle-based multi-modal imaging

Shin, Tae Hyun; Choi, Yong Je; Kim, Soojin; Cheon, Jinwoo

doi:10.1039/c4cs00345d

Cited by 523 publications

(415 citation statements)

References 50 publications

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“…[759] In an effective approach, core-satellite compounds were developed by decorating 30 nm dye-doped silica nanoparticles with 9 nm iron oxide (Fe 3 O 4 ) nanoparticles. [760] They were used for acquiring MRI and optical imaging of polysialic acid (PSA)-positive cells and exhibited increased T 2 MRI and fluorescence signal compared to individual iron oxide nanoparticles conjugated with optical dyes. [729a] In another strategy, a silica shell was used to encapsulate both MNPs and fluorescent units [761] to enhance the photostability of organic dyes through protecting them against photochemical destruction and photobleaching.…”

Section: Optical Imagingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Optical Imagingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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“…In addition, they can also be conjugated with a targeting moeity for specific imaging. Consequently, a plethora of various natural and synthetic organic and inorganic nanomaterials differing in size, shape, structure, chemistry and architecture have been explored for use as MRI contrast agents [36][37][38][39]. Among the different nanosystems established for MRI, dendrimers are of particular interest because of their welldefined molecular structure and multivalent cooperativity confined within a nanosize volume [36,37,[40][41][42].…”

Section: Mri Contrast Agents Based On Dendrimer Nanotechnologymentioning

confidence: 99%

Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

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Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging (MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast. Dendrimers, a special family of synthetic macromolecules, constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size, branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging.

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“…24 About 0.95 mmoL of Gd(NO 3 Þ 3 Á 6H 2 O and 0.05 mmoL of Eu(NO 3 Þ 3 Á 6H 2 O were taken in a beaker and dissolved in 25 mL deionized water. The mixture solution was magnetically stirred for few minutes and 25 wt.% NH 4 OH solution was added to raise the pH value to 10. The pH plays a major role in the formation of nanorods.…”

Section: Preparation Of Europium-doped Gadolinium Hydroxide Nanorodsmentioning

confidence: 99%

“…The sensitivity of optical imaging is about 10 À12 moles of label detected, whereas the sensitivity of MRI ranges from 10 À9 to 10 À6 moles of label detected. 4,5 MRI is a noninvasive three-dimensional imaging of soft tissues, especially cancer cells. The advantage of using MRI is its high spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

Silica-Coated Europium-Doped Gadolinium Oxide Nanorods for Dual-Modal Imaging of Cancer Cells

Gayathri

Kumar

Panigrahi

et al. 2017

NANO

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Dual-modal imaging of cancer cells is possible with the silica-coated europium-doped gadolinium oxide nanorods due to their magnetic and luminescent properties. In the synthesized nanorods, europium ions serve as`luminescent centers' facilitating optical imaging and gadolinium oxide acts as the contrast agent for magnetic resonance imaging (MRI). This article reports the synthesis method of the europium-doped gadolinium oxide (Eu:Gd 2 O 3 Þ nanorods by the co-precipitation method. The prepared nanorods are further coated with silica to improve its biocompatibility. From the x-ray di®raction (XRD) data, the crystallinity was found to decrease due to the amorphous nature of the silica. Transmission electron microscopy (TEM) studies show that Eu:Gd 2 O 3 nanorods with a length of $ 600 nm and diameter of $ 40 nm were formed. Silica was coated uniformly with the thickness of $ 15 nm. Fourier transform infrared spectroscopy (FTIR) con¯rms the presence of silica in the prepared nanorods. Emission at 611 nm due the presence of Eu 3þ ions was observed. The life time of uncoated and silica-coated nanorods was calculated to be 1.1 ms and 0.9 ms, respectively. In vitro cytotoxicity of the synthesized nanorods in MG63 (human osteosarcoma cell line) was assessed by MTT assay. In vitro MRI studies reveal that the prepared nanorods can be used for T 1 contrast enhancement.

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Recent advances in magnetic nanoparticle-based multi-modal imaging

Cited by 523 publications

References 50 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Dendrimer-based magnetic resonance imaging agents for brain cancer

Silica-Coated Europium-Doped Gadolinium Oxide Nanorods for Dual-Modal Imaging of Cancer Cells

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