Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting

Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO3nanoparticles for synergistic chemotherapy

“…The cores pre-coating agent (DOPA) tightly reacts with platinum cations (at the carbonate and calcium ion interface) 32 resulting in the production of stable precipitates, keeping the nano-precipitates sizes in-check and averts the potential aggregation during the centrifugation. The outer covering lipids were cautiously picked as they greatly influence NPs pharmacokinetics and tissue distribution, 33 hence HSPC, CHOL and DSPE-PEG-2000 (11 : 1 : 1) coating layer were encrusted onto the CDDP-CC cores for a stable NPs generation; with OA also being added onto our final formulation at this stage. Finally, centrifugation was performed to get rid of the unbound drug and free liposomes from the hydrated CDDP/OA-LCC NPs.…”

Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)

“…The exploration of the optimal treatment scheme and DI for different populations requires substantial research in order to maximize the effectiveness of clinical treatment. At present, certain studies focus on optimizing the physical and chemical properties of drugs and increasing the response of patients to anticancer drugs by increasing the local concentration following drug absorption (75,76). In addition, the reduction of adverse reactions and the improvement of the performance status can increase the DI of chemotherapy and improve the curative effect (77,78).…”

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

“…Furthermore, accurate identification and isolation of phytoconstituents in active form demand considerable time and expense. Extracts of many phytoconstituents display structural biological fragility, early drug loss via quick clearance, frequent biotransformation, and gastric or enzymatic destruction [ 17 ]. Thus, a novel strategy that encourages cancer cell-specific targeting through the use of nanotechnology is a current research trend to overcome these negative effects [ 18 ].…”

“…In order to meet unmet requirements, nanotechnology has transformed the pharmaceutical and medical industries. Enhancing solubility, bioavailability, toxicity, pharmacological activity, stability, maintaining the release profile, and physical and chemical stability are further benefits of nano-based herbal development that help achieve desired safety and efficacy [ 17 ].…”