Recent advances in late‐stage selective deuteration for drug development
Xuan Wang,
Yu‐Bo Luo,
Yun‐Xia Luo
et al.
Abstract:Deuteration has emerged as a significant method for investigating kinetic isotope effects in chemical reactions. In recent years, research on deuteration has revealed that this reaction often alters the pharmacokinetic or toxicological properties of drug molecules, thereby enhancing their therapeutic effect. Therefore, deuteration is considered as a potential avenue for drug research direction. Since the approval of the first deuterated drug, “deutetrabenazine,” by the American Food and Drug Administration (FD… Show more
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