Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease

Pishbin, Esmail; Fatemeh, Sadri; Dehghan, Amin; Kiani, Mohammad Javad; Hashemi, Nader; Zare, Iman; Mousavi, Pegah; Rahi, Amid

doi:10.1016/j.envres.2023.115705

Cited by 10 publications

(1 citation statement)

References 106 publications

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“…11,12 Several types of forces can be used for manipulating the fluids and particles in micro scales. [13][14][15][16] The motion of fluids in centrifugal microfluidics is controlled by centrifugal, corio-lis and Euler forces generated by the rotation of the disc. The angular velocity, acceleration rate, rotating direction of the disc, and the geometry of the channel are critical parameters for controlling fluid flow from the center toward the outer side of the CD.…”

Section: Introductionmentioning

confidence: 99%

Real-time monitoring and actuation of a hybrid siphon valve for hematocrit-independent plasma separation from whole blood

Khodadadi,

Pishbin,

Eghbal

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Real-time monitoring and actuation of a hybrid siphon valve for hematocrit-independent plasma separation from whole blood

Khodadadi,

Pishbin,

Eghbal

et al. 2023

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Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

Sharma,

Tyagi,

Chandra

et al. 2024

Exosomes Based Drug Delivery Strategies for Brain Disorders

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miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia

Manzini,

Cappelletti,

Orefice

et al. 2024

Mol Neurobiol

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Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer’s disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT and AD patients. Increased levels of the same miRNAs were found also in CSF derived from FTD group compared to CTs. No differences were observed in expression levels of miR-320b among the three groups. Worthy of note, all miRNAs analysed were increased in an FTD cell model, MAPT IVS10 + 16 neurons. Our results suggest that miR-92a and miR-320a in NDEVs could be proposed as FTD biomarkers.

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Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease

Cited by 10 publications

References 106 publications

Real-time monitoring and actuation of a hybrid siphon valve for hematocrit-independent plasma separation from whole blood

Real-time monitoring and actuation of a hybrid siphon valve for hematocrit-independent plasma separation from whole blood

Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia

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