Recent advances in hypertension research

Mrowka, Ralf

doi:10.1111/apha.13295

Cited by 5 publications

(3 citation statements)

References 18 publications

(22 reference statements)

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“…According to Global Health Observatory data, 1.13 billion people globally are affected with elevated blood pressure (BP), which increases morbidity of conditions such as left ventricular hypertrophy, coronary heart disease, heart failure, atrial fibrillation, and peripheral artery disease (Lewington et al, 2002;Manolis et al, 2015;Mrowka, 2019;Wei et al, 2017). Hypertension itself, however, may not be associated with symptoms (Dorans et al, 2018;Khoury and Ratchford, 2018;Whelton et al, 2018).…”

Section: Cardiovascular Abnormalities and Ca 2+channel Antagonistsmentioning

confidence: 99%

Store-operated calcium channels: Potential target for the therapy of hypertension

Sukhwinder

Anureet

Naranjan

2019

Reviews in Cardiovascular Medicine

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Effective therapy of hypertension represents a key strategy for reducing the burden of cardiovascular disease and its associated mortality. The significance of voltage dependent L-type Ca 2+ channels to Ca 2+ influx, and of their regulatory mechanisms in the development of heart disease, is well established. A wide variety of L-type Ca 2+ channel inhibitors and Ca 2+ antagonists have been found to be beneficial not only in the treatment of hypertension, but also in myocardial infarction and heart failure. Over the past two decades, another class of Ca 2+ channel-the voltage independent store-operated Ca 2+ channel-has been implicated in the regulation and fine tuning of Ca 2+ entry in both cardiac and smooth muscle cells. Storeoperated Ca 2+ channels are activated by the depletion of Ca 2+ stores within the endoplasmic/sarcoplasmic reticulum, or by low levels of cytosolic Ca 2+ , thereby facilitating agonist-induced Ca 2+ influx. Store-operated Ca 2+ entry through this pivotal pathway involves both stromal interaction molecule (STIM) and Orai channels. Different degrees of changes in these proteins are considered to promote Ca 2+ entry and hence contribute to the pathogenesis of cardiovascular dysfunction. Several blockers of storeoperated Ca 2+ channels acting at the level of both STIM and Orai channels have been shown to depress Ca 2+ influx and lower blood pressure. However, their specificity, safety, and clinical significance remain to be established. Thus, there is an ongoing challenge in the development of selective inhibitors of store-operated Ca 2+ channels that act in vascular smooth muscles for the improved treatment of hypertension.

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Section: Cardiovascular Abnormalities and Ca 2+channel Antagonistsmentioning

confidence: 99%

Store-operated calcium channels: Potential target for the therapy of hypertension

Sukhwinder

Anureet

Naranjan

2019

Reviews in Cardiovascular Medicine

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“…La HTA es un problema creciente de salud mundial y afecta a 1.13 millardos de personas 57 . El control sigue siendo subóptimo, con índices tan altos como del 40 % o más de los pacientes hipertensos 58 .…”

Section: Grupo II (Hta)unclassified

Correlación entre el grado de hipertensión arterial y el índice de estrés oxidativo. Estudio de cohorte en una población de pacientes hipertensos sistémicos en República Dominicana

Núñez-Musa¹,

Núñez‐Sellés

Rossi³

et al. 2019

cysa

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Introducción: la hipertensión arterial (HTA) es una de las mayores cargas de enfermedad y riesgo para infarto cardíaco, la insuficiencia cardíaca y el fallo renal. Se reconoce que el estrés oxidativo (EO) es un determinante en el desarrollo de complicaciones y el progreso de la HTA. Se determinó el índice de EO (IEO) en individuos con HTA y en un grupo sano control, para evaluar su posible correlación. Materiales y métodos: se midió IEO en una población de 112 individuos con HTA de distintos grados entre 50 y 70 años escogidos al azar y se comparó con los valores de un grupo control de voluntarios sanos, con la intención de definir el grado de correlación entre los niveles del IEO y la severidad de HTA, mediante la medición de biomarcadores para el EO en lisado de eritrocitos. Resultados: a pesar de que los beneficios de la terapia antioxidante (TAO) no han sido definitivamente probadas, en gran parte porque las enfermedades complejas no dependen de un solo componente fisiopatogénico, el EO sigue siendo una piedra angular en el desarrollo de complicaciones y el empeoramiento de los cuadros clínicos de muchos padecimientos. La demostración de biomarcardores específicos mejora la posibilidad de una TAO dirigida. El presente ensayo demostró que la edad, el género y la etnia no influyen en el IEO y que el EO fue severo en los casos de HTA III, moderado en HTA II y estuvo ausente en el subgrupo con HTA grado I. Conclusiones: estos resultados sugieren una relación entre los niveles de EO y severidad de HTA y sustenta evidencias para diseñar nuevos ensayos clínicos que evalúen la eficacia de una TAO adyuvante en el manejo de la HTA.

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“…Hypertension (HTN) is a chronic disease prevalent worldwide [1][2][3]. According to the World Health Organization, more than 1 billion people have suffered from HTN since 2019 [4]. In their study on the global epidemiology of HTN, Mill et al reported that 1.39 billion out of the adult population suffered from HTN, and the prevalence of adult HTN was higher in low-and middle-income countries than in high-income countries [5].…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive Effects of IGTGIPGIW Peptide Purified from Hippocampus abdominalis: p-eNOS and p-AKT Stimulation in EA.hy926 Cells and Lowering of Blood Pressure in SHR Model

Lee

Kim

et al. 2022

Marine Drugs

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The aim of this study was to assess the potential hypertensive effects of the IGTGIPGIW peptide purified from Hippocampus abdominalis alcalase hydrolysate (HA) for application in the functional food industry. We investigated the antihypertensive effects of IGTGIPGIW in vitro by assessing nitric oxide production in EA.hy926 endothelial cells, which is a major factor affecting vasorelaxation. The potential vasorelaxation effect was evaluated using 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate, a fluorescent stain. IGTGIPGIW significantly increased the expression of endothelial-derived relaxing factors, including endothelial nitric oxide synthase and protein kinase B, in EA.hy926 cells. Furthermore, oral administration of IGTGIPGIW significantly lowered the systolic blood pressure (183.60 ± 1.34 mmHg) and rapidly recovered the diastolic blood pressure (143.50 ± 5.55 mmHg) in the spontaneously hypertensive rat model in vivo. Our results demonstrate the antihypertensive activity of the IGTGIPGIW peptide purified from H. abdominalis and indicate its suitability for application in the functional food industry.

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Recent advances in hypertension research

Cited by 5 publications

References 18 publications

Store-operated calcium channels: Potential target for the therapy of hypertension

Store-operated calcium channels: Potential target for the therapy of hypertension

Correlación entre el grado de hipertensión arterial y el índice de estrés oxidativo. Estudio de cohorte en una población de pacientes hipertensos sistémicos en República Dominicana

Antihypertensive Effects of IGTGIPGIW Peptide Purified from Hippocampus abdominalis: p-eNOS and p-AKT Stimulation in EA.hy926 Cells and Lowering of Blood Pressure in SHR Model

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