Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes

Anwar, Doaa M.; El-Sayed, Mousa; Reda, Asmaa; Fang, Jia‐You; Khattab, Sherine N.; Elzoghby, Ahmed O.

doi:10.1080/17425247.2021.1955853

Cited by 28 publications

(16 citation statements)

References 131 publications

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“…The surface of magnetic NC was decorated by hydroxyapatite that was cross-linked with β-cyclodextrin leading to the improvement in curcumin bioavailability. The therapeutic efficiency was established by the reduction in tumor size ( 274 , 275 ). In another research, nano curcumin was combined with rare-earth-doped upconversion nanoparticles (UCNPs).…”

Section: Future Prospectsmentioning

confidence: 99%

“…Berberine with etoposide via albumin nanoparticle was used in the Nano-in Nano approach. Co-encapsulation of BER was hypothesized to reduce the therapeutic dose of ETP, which would minimize its toxicity and overcome the problem of developing resistance and enhance its antitumor efficacy ( 275 ). When given in lung cancer-bearing mice, it leads to a decrease in vascular endothelial growth factor (VEGF) expression level, triggered caspase activation with tumor cell apoptosis, and enhanced antiangiogenic effect that might refer to synergistic topoisomerase II inhibition and reduction of multidrug resistance (MDR) effect in A549 cells ( 232 , 275 , 277 ).…”

Section: Future Prospectsmentioning

confidence: 99%

“…Co-encapsulation of BER was hypothesized to reduce the therapeutic dose of ETP, which would minimize its toxicity and overcome the problem of developing resistance and enhance its antitumor efficacy ( 275 ). When given in lung cancer-bearing mice, it leads to a decrease in vascular endothelial growth factor (VEGF) expression level, triggered caspase activation with tumor cell apoptosis, and enhanced antiangiogenic effect that might refer to synergistic topoisomerase II inhibition and reduction of multidrug resistance (MDR) effect in A549 cells ( 232 , 275 , 277 ). Thus, various plants possessing anticancer properties can be formulated with modifications to make them suitable for use as a theranostic leading to a substantial increase in the potency of anticancer drugs in the future.…”

Section: Future Prospectsmentioning

confidence: 99%

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Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

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Section: Future Prospectsmentioning

confidence: 99%

Section: Future Prospectsmentioning

confidence: 99%

Section: Future Prospectsmentioning

confidence: 99%

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Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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“…However, some studies showed that particles with a size in the range of 100–150 nm with a positive charge enter tumor cells more easily. 30–32 Fig. 1 shows the properties of nanoparticle drug delivery systems that determine their activity.…”

Section: Essential Properties Of Paclitaxel Nanomedicinementioning

confidence: 99%

“…100,101 Membrane coating has also been accomplished using ultrasonic energy and microfluidic instruments in addition to physical extrusion. 29,30 This success cleared the path for biomimetic nanomedicine to be developed utilizing cell membranes obtained from other cells. 97…”

Section: Recent Applications Of Ptx Nanomedicine For the Treatment Of...mentioning

confidence: 99%

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

et al. 2022

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The role of cell‐penetrating peptides in potential anti‐cancer therapy

Zhou

Zou

Cheng

et al. 2022

Clinical & Translational Med

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Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site. Cell‐penetrating peptides (CPPs) are typically made up of 5–30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti‐cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs‐based drug delivery strategy could be improved by clever design or chemical modifications to develop the next‐generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.

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Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes

Cited by 28 publications

References 131 publications

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

The role of cell‐penetrating peptides in potential anti‐cancer therapy

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