Recent Advances in Hepatitis B Treatment

Prifti, Georgia-Myrto; Moianos, Dimitrios; Giannakopoulou, Erofili; Pardali, Vasiliki; Tavis, John E.; Zoidis, Grigoris

doi:10.3390/ph14050417

Cited by 33 publications

(24 citation statements)

References 208 publications

(311 reference statements)

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“…The DNA polymerase encoded by the P region is a multifunctional protein with reverse transcriptase (RT) and DNA polymerase activities. The regulatory protein X encoded by the X region can directly or indirectly regulate the expression of the host and virus genomes [ 26 ]. Due to the lack of proofreading function of the HBV polymerase, the high error rate occurs during HBV replication, resulting in the HBV genome being prone to mutation compared with other DNA viruses [ 27 ].…”

Section: Formation Mechanism Of Persistent Low-level Hbsag Expressionmentioning

confidence: 99%

Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

Dai

et al. 2022

Journal of Immunology Research

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Among HBV-infected persons, there is a group of people with hepatitis B surface antigen (HBsAg) showing persistently low levels of expression. The production of low-level HBsAg does not mean a good outcome of chronic HBV infection. Patients still have virus replication and sustained liver damage, and they have the potential to transmit the infection. This risk poses a challenge to clinical diagnosis and blood transfusion safety and is a major concern of experts. However, the mechanism behind persistent low-level HBsAg expression in serum is not completely clear, and complete virus clearance by the host is vital. In this review, we summarize the research progress on the mechanism behind low-level expression of HBsAg in patients with chronic HBV infection in recent years.

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Section: Formation Mechanism Of Persistent Low-level Hbsag Expressionmentioning

confidence: 99%

Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

Dai

et al. 2022

Journal of Immunology Research

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“…Despite available well-functioning vaccines and inhibitors targeting various steps of the virus life cycle (recently reviewed in [95]), hepatitis B-virus (HBV), an enveloped DNA virus, remains a major health problem [96]. HBV replication depends on a step catalyzed by error-prone reverse transcriptase, and has therefore been included among RNA viruses with low fidelity polymerases in this review.…”

Section: Hepatitis B Virus Assembly Inhibitorsmentioning

confidence: 99%

Targeting the Virus Capsid as a Tool to Fight RNA Viruses

Hozáková

Vokatá

Ruml

et al. 2022

Viruses

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Several strategies have been developed to fight viral infections, not only in humans but also in animals and plants. Some of them are based on the development of efficient vaccines, to target the virus by developed antibodies, others focus on finding antiviral compounds with activities that inhibit selected virus replication steps. Currently, there is an increasing number of antiviral drugs on the market; however, some have unpleasant side effects, are toxic to cells, or the viruses quickly develop resistance to them. As the current situation shows, the combination of multiple antiviral strategies or the combination of the use of various compounds within one strategy is very important. The most desirable are combinations of drugs that inhibit different steps in the virus life cycle. This is an important issue especially for RNA viruses, which replicate their genomes using error-prone RNA polymerases and rapidly develop mutants resistant to applied antiviral compounds. Here, we focus on compounds targeting viral structural capsid proteins, thereby inhibiting virus assembly or disassembly, virus binding to cellular receptors, or acting by inhibiting other virus replication mechanisms. This review is an update of existing papers on a similar topic, by focusing on the most recent advances in the rapidly evolving research of compounds targeting capsid proteins of RNA viruses.

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“…HBV causes acute and chronic liver disease and is endemic in many areas of the world. The virus is transmitted through contact with blood or other body fluids from an infected person (Guvenir and Arikan., 2020;Prifti et al, 2021). Polymerase chain reaction is one of the most powerful technologies in the molecular biology, was invented by Mullis in 1983 and patented in1985.…”

Section: Introductionmentioning

confidence: 99%

Applying RT-PCR standard detection procedures of HBV and HCV in Wasit blood bank

Alkhateeb¹,

Maleek²,

Faraj³

2022

ijhs

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Background: Blood and blood products are a unique and precious resource because they can be obtained only from individuals who donate blood or its components. Aim of the study: To increase the safety of blood given to patients by evaluating the addition of new investigations to detect HBV and HCV of donated blood in the blood bank. Patients and Methods: this study included 150 samples of blood taken from the blood bags of donors from the blood bank /Wasit Province. In this study used ELISA (as serological method) & RT-PCR (as molecular method) to detect infection with hepatitis B virus and hepatitis C virus. Results: The results of ELISA test, from 150 analyzed samples, only 6/150 (4.0%) of the patients were diagnosed infection by HCV and 1/150 (0.6%) infection by HBV. The results of PCR test, (4.0%) and (5.3%) for HCV C and HBV respectively. Conclusion: Diagnosis of hepatitis virus (B, C) by ELISA is still sufficient.

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Recent Advances in Hepatitis B Treatment

Cited by 33 publications

References 208 publications

Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

Targeting the Virus Capsid as a Tool to Fight RNA Viruses

Applying RT-PCR standard detection procedures of HBV and HCV in Wasit blood bank

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