Recent advances in guar gum based drug delivery systems and their administrative routes

Verma, Diksha; Sharma, Sunil K.

doi:10.1016/j.ijbiomac.2021.03.087

Cited by 82 publications

(27 citation statements)

References 153 publications

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“…They combined a poly (lactic-co-glycolic acid) (PLGA) nanoparticle formulation with a GG film matrix to make a peptide carrier. Due to the gradual release of the GG film, the peptide can make more intimate and long-lasting contact with the buccal epithelium [34].  Antigen (Ag85A)-loaded GG nanoparticles (NPs) were developed to administer a tuberculosis vaccine orally [35].…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

The Applications of food hydrocolloids in drug delivery system

Tamkeen

Kukatil

Rahman

et al. 2022

GJPB

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Food hydrocolloids are multifunctional natural substances that are being exploited to create a new generation of functional foods that improve health and well-being. Pharmaceutical and culinary formulations play a crucial role in rheology, tribology, and intuition. According to current research, hydrocolloids have the potential to tailor nutritional value and deliver therapeutic benefits by lowering plasma cholesterol, postprandial glucose, glycemic response, insulin secretion, and preventing colon cancer by controlling meal transit, digestion, and gastric emptying. They also enhance the bioavailability of specific bioactive moieties and drugs by delivering them to the gastrointestinal tract in a regulated and targeted manner. The use of food hydrocolloids, particularly proteins and polysaccharides, as viscosity modifiers, gelling, coating, stabilizing agents, and emulsifiers in the drug delivery system and the nutraceutical potential utility of food colloids as functional components, are discussed in this article.

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Section: Applications In Drug Deliverymentioning

confidence: 99%

The Applications of food hydrocolloids in drug delivery system

Tamkeen

Kukatil

Rahman

et al. 2022

GJPB

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“…Both oral and mucosal administrations are not ideal with chitosan as the pH sensitivity in acidic conditions results in rapid degradation in the stomach, while the low solubility in water limits the desirable mucoadhesive properties, resulting in poor absorption through mucosal sites [117]. Other polysaccharides such as pectin and guar gum are also associated with limitations, such as poor mechanical stability [118,119]. However, many of these limitations can be addressed through surface modification or incorporation of other molecules.…”

Section: Challenges In Hydrogel Drug Delivery System Developmentmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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“…Control films (with GG and glycerol only) showed some distinct absorption bands: at the region from 3650 to 3000 cm − 1 which is commonly associated with the stretching vibration of O -H bond (Borges et al, 2013;Lei et al, 2019), in the region 3000− 2800 cm − 1 that is attributed to CHbond stretching (Cano et al, 2015;Gutiérrez et al, 2016), centered around 1645 cm − 1 which is related to bending vibration of O -H (Borges et al, 2013;Meira et al, 2017), centered around 1370 cm − 1 that refer to the stretching of Amide III band coming from the protein in the gum (GG contains 5 % by wt. proteins) (Pelissari et al, 2013b;Verma & Sharma, 2021), reaching from 1200 to 900 cm − 1 centered around 1053 cm − 1 which corresponds to stretching vibration of C-OHbonds which the film had in abundance due to GG being a galactomannan polymer (Cano et al, 2015;Meira et al, 2017;Pelissari et al, 2013b).…”

Section: Fourier-transform Infrared (Ftir) Spectroscopymentioning

confidence: 99%

Assessment of the performance of several novel approaches to improve physical properties of guar gum based biopolymer films

Kırtıl

Aydoğdu

Svitova

et al. 2021

Food Packaging and Shelf Life

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Biopolymer-based films are natural, renewable, nontoxic and biodegradable alternatives to plastic packaging. Despite years of ongoing research, biopolymer films still lag much behind plastic films in mechanical and barrier properties. In this study, guar gum (GG) based films were prepared to evaluate the potential of some novel applications in enhancing films physical properties. For this purpose, GG and glycerol based films were prepared with varying amounts of orange peel oil (1%, 2% v/v), and/or reinforced with halloysite nanotubes (HNT), and crosslinked with sodium trimetaphosphate (STMP). Oil incorporation, despite weakening films' mechanical strength, increased film hydrophobicity and enhanced its water barrier properties. Crosslinking, decreased films' relatively high solubility while also improving other film properties. Orange peel oil preserved its antimicrobial activity and HNT stabilized GG films provided controlled release of volatile essential oil. Findings indicated the possibility of improving physical properties of GG films with the methods employed.

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Recent advances in guar gum based drug delivery systems and their administrative routes

Cited by 82 publications

References 153 publications

The Applications of food hydrocolloids in drug delivery system

The Applications of food hydrocolloids in drug delivery system

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Assessment of the performance of several novel approaches to improve physical properties of guar gum based biopolymer films

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