Recent Advances in Green Nanoparticulate Systems for Drug Delivery: Efficient Delivery and Safety Concern

Abstract

Nanotechnology manipulates therapeutic agents at the nanoscale for the development of nanomedicines. However, there are current concerns over nanomedicines, mainly related to the possible toxicity of nanomaterials used for health medications. Due to their small size, they can enter the human body more readily than larger sized particles. Green chemistry encompasses the green synthesis of drug-loaded nanoparticles by reducing the use of hazardous materials in the synthesis process, thus reducing the adverse health impacts of pharmaceutics. This would greatly expand their potential in biomedical treatments. This review highlights the potential risks of nanomedicine formulations to health, delivery routes of green nanomedicines, recent advances in the development of green nanoscale systems for biomedical applications and future perspectives for the green development of nanomedicines.

Nano based drug delivery systems: recent developments and future prospects

“…Nanoscale sized particles exhibit unique structural, chemical, mechanical, magnetic, electrical, and biological properties. Nanomedicines have become well appreciated in recent times due to the fact that nanostructures could be utilized as delivery agents by encapsulating drugs or attaching therapeutic drugs and deliver them to target tissues more precisely with a controlled release [ 10 , 19 ]. Nanomedicine, is an emerging field implementing the use of knowledge and techniques of nanoscience in medical biology and disease prevention and remediation.…”

“…The green chemistry route of designing nanoparticles loaded with drugs is widely encouraged as it minimises the hazardous constituents in the biosynthetic process. Thus, using green nanoparticles for drug delivery can lessen the side-effects of the medications [ 19 ]. Moreover, adjustments in nanostructures size, shape, hydrophobicity, and surface changes can further enhance the bioactivity of these nanomaterials.…”

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

“…Thus, the promises of nanotechnology rest on fine tuning and careful characterization of the underlying materials and methods. Interestingly, the concept of ‘green’ nanotechnology, using biodegradable and eco-friendly materials, is gaining ground [ 222 , 223 ]. The combination of green nanotechnology and the natural phytochemicals sounds promising.…”

Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma

“…However, it is important to underline that the use of some materials can be potentially risky for patients' health [27]. In fact, carbon nanotubes, metal-based nanoparticles or even polymeric nanoparticles have been widely investigated and used for possible clinical applications.…”