Recent advances in graphene monolayers growth and their biological applications: A review

Devika, M.; Nandanapalli, Koteeswara Reddy; Lee, Sungwon; Hahn, Yoon‐Bong

doi:10.1016/j.cis.2020.102225

Cited by 21 publications

(6 citation statements)

References 179 publications

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“…In recent years, many potential graphene applications have emerged across different research and innovation fields 3 , 7 , 8 , 50 , 51 . The growing interest in this material has led to an increase in its production—and, consequently, in human exposure to it.…”

Section: Discussionmentioning

confidence: 99%

Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells

Frontiñán-Rubio

González

Vázquez

et al. 2022

Sci Rep

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Graphene and its derivative materials are manufactured by numerous companies and research laboratories, during which processes they can come into contact with their handlers' physiological barriers—for instance, their respiratory system. Despite their potential toxicity, these materials have even been used in face masks to prevent COVID-19 transmission. The increasingly widespread use of these materials requires the design and implementation of appropriate, versatile, and accurate toxicological screening methods to guarantee their safety. Murine models are adequate, though limited when exploring different doses and lengths of exposure—as this increases the number of animals required, contrary to the Three R's principle in animal experimentation. This article proposes an in vitro model using primary, non-transformed normal human bronchial epithelial (NHBE) cells as an alternative to the most widely used model to date, the human lung tumor cell line A549. The model has been tested with three graphene derivatives—graphene oxide (GO), few-layer graphene (FLG), and small FLG (sFLG). We observed a cytotoxic effect (necrosis and apoptosis) at early (6- and 24-h) exposures, which intensified after seven days of contact between cells and the graphene-related materials (GRMs)—with cell death reaching 90% after a 5 µg/mL dose. A549 cells are more resistant to necrosis and apoptosis, yielding values less than half of NHBE cells at low concentrations of GRMs (between 0.05 and 5 µg/mL). Indeed, GRM-induced cell death in NHBE cells is comparable to that induced by toxic compounds such as diesel exhaust particles on the same cell line. We propose NHBE as a suitable model to test GRM-induced toxicity, allowing refinement of the dose concentrations and exposure timings for better-designed in vivo mouse assays.

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Section: Discussionmentioning

confidence: 99%

Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells

Frontiñán-Rubio

González

Vázquez

et al. 2022

Sci Rep

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“…Not many studies exist that deal with structure prediction in quasi-two-dimensional systems, which would correspond to either multi-(mono-)layer systems such as two/three-layer graphene systems that are of interest because of their electronic properties [ 79 , 80 ]. The classical quasi-two-dimensional systems would correspond to the individual layers of the so-called layered compounds such as the transition metal dichalcogenides, where the atoms inside the layers are strongly bonded via covalent bonds or ionic interactions, and the interaction between the layers is based on van der Waals interactions or the electrostatic interactions between the first non-vanishing (higher-order) electric multipoles of the layers.…”

Section: Examplesmentioning

confidence: 99%

Structure prediction in low dimensions: concepts, issues and examples

Schön

2023

Phil. Trans. R. Soc. A.

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Structure prediction of stable and metastable polymorphs of chemical systems in low dimensions has become an important field, since materials that are patterned on the nano-scale are of increasing importance in modern technological applications. While many techniques for the prediction of crystalline structures in three dimensions or of small clusters of atoms have been developed over the past three decades, dealing with low-dimensional systems—ideal one-dimensional and two-dimensional systems, quasi-one-dimensional and quasi-two-dimensional systems, as well as low-dimensional composite systems—poses its own challenges that need to be addressed when developing a systematic methodology for the determination of low-dimensional polymorphs that are suitable for practical applications. Quite generally, the search algorithms that had been developed for three-dimensional systems need to be adjusted when being applied to low-dimensional systems with their own specific constraints; in particular, the embedding of the (quasi-)one-dimensional/two-dimensional system in three dimensions and the influence of stabilizing substrates need to be taken into account, both on a technical and a conceptual level. This article is part of a discussion meeting issue ‘Supercomputing simulations of advanced materials’.

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“…As one of the most frequently used molecules in graphene functionalization, 1-pyrenebutanoic acid succinimidyl ester (PBASE) is chosen as a linker to assist anchoring of biomolecule. 181 The aromatic pyrenyl group π-stacks with the surface while the succinimidyl ester group specifically reacts with amine terminal groups of the biorecognition molecule to form an amide bond. 182 Up to now, many types of biomolecules have been successfully anchored to graphene through PBASE linkers such as peptides, antibodies, enzymes, and avidin, as well as DNA probes (Fig.…”

Section: Graphene Functionalization For Biochemical Sensingmentioning

confidence: 99%

Review—Recent Advances in Graphene-Based Field-Effect-Transistor Biosensors: A Review on Biosensor Designing Strategy

Hao

Moro

et al. 2022

J. Electrochem. Soc.

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Biosensors for quick diagnosis and in situ monitoring are increasingly needed in health care. Field-effect transistor based biosensors have attracted much attention due to their high sensitivity and compatibility with point-of-care applications. As the most important 2D material, graphene has been investigated intensively as a channel material for transistor-based sensors due to its easily enhanced selectivity by rather simple functionalization. However, in order to realize its practical applications, challenges still remain, such as device stability and reproducibility. Here, we review recent progress in the general design strategy of high-performance graphene field-effect transistor biosensors with emphasis on the device physics, defects, Debye screening, and functionalization. Finally, both current applications and perspectives on future development are given.

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Recent advances in graphene monolayers growth and their biological applications: A review

Cited by 21 publications

References 179 publications

Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells

Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells

Structure prediction in low dimensions: concepts, issues and examples

Review—Recent Advances in Graphene-Based Field-Effect-Transistor Biosensors: A Review on Biosensor Designing Strategy

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