Recent advances in gold nanoparticle-based bioengineering applications

Abstract

Plasmonic nanoparticle based nanotechnology plays a pivotal role in the recent advances in biomedical applications. Along with biocompatibility and robust surface chemistry, the tunable optical properties of the visible and near-infrared regions of gold nanoparticles have attracted significant attention for a wide range of biomedical applications such as in-vitro biosensing, in-vivo imaging, drug delivery, and tissue engineering. In this review we focus on the the recent advances in biomedical applications based on the use of plasmonic nanoparticles, which have been developed to solve the limitations of current technologies in biosensing, bioimaging, therapeutic drug delivery, and tissue engineering applications.

From a precursor to an etchant: spontaneous inversion of the role of Au(iii) chloride for one-pot synthesis of smooth and spherical gold nanoparticles

“…Among metal nanoparticles, gold nanoparticles (AuNPs) have been actively studied because of their high biocompatibility, stability, and excellent catalytic, electrical, and optical properties. [1][2][3][4][5][6] In particular, the localized surface plasmon resonance (LSPR) of AuNPs allows them to be used for diverse optical applications, including sensing, 7-9 surface-enhanced Raman scattering, 10 surface-enhanced uorescence, 11 and plasmon resonance energy transfer. 12 It is widely known that the LSPR of AuNPs is greatly affected by their size, shape, and morphology.…”

Colloidal plasmonic gold nanoparticles and gold nanorings: shape-dependent generation of singlet oxygen and their performance in enhanced photodynamic cancer therapy

“…The unique optical properties and associated surface plasmonic resonance (SPR) effects of gold (Au) nanostructures have proven useful for multifaceted biomedical applications including bioimaging, biomolecule sensing, thermally modulated drug delivery, photothermal cancer therapy, photodynamic therapy (PDT), etc. [1][2][3][4][5] Typically, gold nanomaterials exhibit collective electron charge oscillations named localized surface plasmon resonances (LSPRs), through which the optical absorption and scattering can be dramatically enhanced with elevated local near-field amplitude at the resonance frequency. Such LSPR properties greatly depend on the particle shape, size, and dielectric environment.…”

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

“…Their electronic structure make them useful as tools in surface plasmon resonance imaging and as signal amplifiers. Their unique optical properties, due to strong light absorption and scattering, enable sensitive single live cell and in vivo imaging [148]. AuNPs have also been used as radio sensitizers in radiotherapy [145,147].…”

“…They are easily synthesized in various shapes and sizes in aqueous media [146,147] and are of great interest for various biomedical applications, due to their biocompatibility and high chemical and thermal stability [145][146][147][148]. Their electronic structure make them useful as tools in surface plasmon resonance imaging and as signal amplifiers.…”

“…Furthermore, AuNPs act as photothermal transducers by absorbing energy and releasing heat via non-radiative methods, which primarily destroy abnormal cells and tissues such as tumor cells. As they are easily functionalized and modified, AuNPs are ideal carriers for drug and gene delivery [145][146][147][148] and have shown to alter the pharmacokinetics and pharmacodynamics of the loaded drugs. This combination of therapeutics and imaging is known as theranostics [148].…”