Recent advances in genes involved in secondary metabolite synthesis, hyphal development, energy metabolism and pathogenicity in Fusarium graminearum (teleomorph Gibberella zeae)

Geng, Zhiqing; Zhu, Wei; Su, Hao; Yong, Zhao; Zhang, Ke‐Qin; Yang, Jinkui

doi:10.1016/j.biotechadv.2013.12.007

Cited by 40 publications

(24 citation statements)

References 115 publications

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“…These results are consistent with previous studies by genetic methods,i n which conidium production was completely abolished in an AbaA deletion mutant, [22] and the Gpmk1 pathway and LaeA pathway of the velvet complex were involved in conidiation. [29] These results support the idea that FARI is an important inducer of conidia formation of Fusarium species. [29] These results support the idea that FARI is an important inducer of conidia formation of Fusarium species.…”

supporting

confidence: 78%

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium

Cheng

Sun

et al. 2018

Angewandte Chemie

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Asexual and sexual reproduction are the most important biological events in the life cycle of phytopathogenic and toxigenic Fusarium and are responsible for disease epidemics.H owever,t he signaling molecules whichi nduce the asexual reproduction of Fusarium are unknown. Herein we describe the structure elucidation, including the absolute configuration, of Fusarium asexual reproduction inducer (FARI), an ew sesquiterpene derivative,b ys pectroscopic analysis,t otal synthesis,a nd conidium-inducing assays of synthetic isomers.W eh ave also uncovered the universality of FARI among Fusarium species.M oreover,amechanism-ofaction study suggested that the Gpmk1 and LaeA signaling pathwaysa re required for conidium formation induced by FARI;c onversely,t he Mgv1 of mitogen-activated protein kinase is not involved in conidium formation. FARI exhibited conidium-inducing activity at an extremely low dose and high stereoselectivity,w hichm ay suggest the presence of as tereospecific target.

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supporting

confidence: 78%

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium

Cheng

Sun

et al. 2018

Angewandte Chemie

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“…Outbreaks of WHB often cause severe yield losses and contaminations of infested grains with deoxynivalenol (DON), zearalenone and other mycotoxic compounds (Desjardins, 2003). Although conidia also are infectious, ascospores are the primary inoculums in F. graminearum, which overwinters and forms perithecia on plant debris (Osborne and Stein, 2007;Geng et al, 2014). Ascospores are forcibly released from perithecia for dispersal and infection of floral tissues involves the differentiation of compound appressoria or penetrating hyphae (Jansen et al, 2005;Boenisch and Schäfer, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sexual specific functions of Tub1 beta‐tubulins require stage‐specific RNA processing and expression in Fusarium graminearum

Chen

Hao

et al. 2018

Environmental Microbiology

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Summary The wheat head blight fungus Fusarium graminearum has two highly similar beta‐tubulin genes with overlapping functions during vegetative growth but only TUB1 is important for sexual reproduction. To better understand their functional divergence during ascosporogenesis, in this study we characterized the sequence elements important for stage‐specific functions of TUB1. Deletion of TUB1 blocked the late but not initial stages of perithecium formation. Perithecia formed by tub1 mutant had limited ascogenous hyphae and failed to develop asci. Silencing of TUB1 by MSUD also resulted in defects in ascospore formation. Interestingly, the 3′‐UTR of TUB1 was dispensable for growth but essential for its function during sexual reproduction. RIP mutations that specifically affected Tub1 functions during sexual reproduction also were identified in two ascospore progeny. Furthermore, site‐directed mutagenesis showed that whereas the non‐editable mutations at three A‐to‐I RNA editing sites had no effects, the N347D (not T362D or I368V) edited mutation affected ascospore development. In addition, the F167Y, but not E198K or F200Y, mutation in TUB1 conferred tolerance to carbendazim and caused a minor defect in sexual reproduction. Taken together, our data indicate TUB1 plays an essential role in ascosporogenesis and sexual‐specific functions of TUB1 require stage‐specific RNA processing and Tub1 expression.

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“…Fusarium graminearum is the main phytopathogen fungus that causes Fusarium head blight (FHB) in small-grain cereals (Wheat, barley and maize), it causes yield and quality losses and contaminate grains by producing mycotoxins that are hazardous to livestocks and humans [15]. Developing new FHB manage method was urgent because chemical fungicides that have long been used for the management of FHB have met many problems that such as not friendly to environment and human health, stimulate the pathogen's production of mycotoxins [16], or failed to reduce mycotoxin levels low enough for grain acceptance [17].…”

Section: / 30mentioning

confidence: 99%

Comprehensive quantification of N-glycoproteome in Fusarium graminearum reveals intensive glycosylation changes against fungicide

et al. 2016

Journal of Proteomics

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Recent advances in genes involved in secondary metabolite synthesis, hyphal development, energy metabolism and pathogenicity in Fusarium graminearum (teleomorph Gibberella zeae)

Cited by 40 publications

References 115 publications

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium

Sexual specific functions of Tub1 beta‐tubulins require stage‐specific RNA processing and expression in Fusarium graminearum

Comprehensive quantification of N-glycoproteome in Fusarium graminearum reveals intensive glycosylation changes against fungicide

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