Recent advances in fiber-optic DNA biosensors

Wang, Yiming; Pang, Xiaojiao; Zhang, Yuyu

doi:10.4236/jbise.2009.25046

Cited by 14 publications

(4 citation statements)

References 62 publications

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“…The NATOF is fabricated by heat pulling method, utilizing a CO 2 laser [1][2]. For tapering the CO 2 laser beam focused via a Zn-Se lens on the fiber length.…”

Section: Resultsmentioning

confidence: 99%

Kinetic study for the hybridization of 25-mer DNA by nonadiabatic tapered optical fiber sensor

Zibaii

Taghipour

Saeedian

et al. 2011

Optical Sensors and Biophotonics III

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A single-mode nonadiabatic tapered optical fiber (NATOF) sensor was utilized for studying of bimolecular interaction including DNA-DNA interaction. This work presents a simple evanescent wave sensing system based on an interferometric approach, suitable to meet the requirements of lable-free sensor systems for detecting biomolecular interactions. Furthermore basic experiments were carried out, for detecting the hybridization of 25-mer DNA with an immobilized counterpart on the surface. The wavelength shifting showed a Longmuir behavior with time and a redshifted after the bending probe single strand DNA (ssDNA) and target ssDNA to the sensor surface. The hybridization response of complementary strands was measured at three concenteration of 200, 500, 1000 nM of ssDNA target solution. In this experiment binding constant or association constants for ssDNA-ssDNA interaction was measured to be 3.58 ×10 5 M -1 .

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“…The NATOF is fabricated by heat pulling method, utilizing a CO 2 laser [1][2]. For tapering the CO 2 laser beam focused via a Zn-Se lens on the fiber length.…”

Section: Resultsmentioning

confidence: 99%

Kinetic study for the hybridization of 25-mer DNA by nonadiabatic tapered optical fiber sensor

Zibaii

Taghipour

Saeedian

et al. 2011

Optical Sensors and Biophotonics III

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“…Optical fibre biosensors have been widely exploited for the detection of a board range of analytical targets, including viruses, spores, bacterial pathogens, pesticides, toxins and other small molecules from clinical and food samples (Bhunia, 2014;Bosch et al, 2007;Liu et al, 2014;Marazuela and Moreno-Bondi, 2002;Urrutia et al, 2015;Velusamy et al, 2010;Wang et al, 2009). The working principle of the optical fibre biosensors and their applications are well known and have been extensively reviewed (Bosch et al, 2007;Chen and Ding, 2013;Marazuela and Moreno-Bondi, 2002;Wang andWolfbeis, 2016, 2013).…”

Section: Optical Fibre Biosensorsmentioning

confidence: 99%

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

Kant

Shahbazi

Dave

et al. 2018

Biotechnology Advances

141

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Rapid detection of foodborne pathogens at an early stage is imperative for preventing the outbreak of foodborne diseases, known as serious threats to human health. Conventional bacterial culturing methods for foodborne pathogen detection are time consuming, laborious, and with poor pathogen diagnosis competences. This has prompted researchers to call the current status of detection approaches into question and leverage new technologies for superior pathogen sensing outcomes. Novel strategies mainly rely on incorporating all the steps from sample preparation to detection in miniaturized devices for online monitoring of pathogens with high accuracy and sensitivity in a time-saving and cost effective manner. Lab on chip is a blooming area in diagnosis, which exploits different mechanical and biological techniques to detect very low concentrations of pathogens in food samples. This is achieved through streamlining the sample handling and concentrating procedures, which will subsequently reduce human errors and enhance the accuracy of the sensing methods. Integration of sample preparation techniques into these devices can effectively minimize the impact of complex food matrix on pathogen diagnosis and improve the limit of detections. Integration of pathogen capturing bio-receptors on microfluidic devices is a crucial step, which can facilitate recognition abilities in harsh chemical and physical conditions, offering a great commercial benefit to the food-manufacturing sector. This article reviews recent advances in current state-of-the-art of sample preparation and concentration from food matrices with focus on bacterial capturing methods and sensing technologies, along with their advantages and limitations when integrated into microfluidic devices for online rapid detection of pathogens in foods and food production line.

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“…Biosensors based on fluorescence resonance energy transfer (FRET) technology, which are used in probe-based assays for quantitative PCR (qPCR), make use of the transfer of energy from a donor fluorophore to an acceptor fluorophore when appreciable overlap exists between the absorption spectrum of the acceptor and the emission spectrum of the donor. This technology has also been used in screening gene mutations, measuring gene expression, and in quantifying viral loads [ 34 , 35 , 36 , 37 ].…”

Section: Dna-based Nanobiosensors For Detection Of Infectious Disementioning

confidence: 99%

DNA-Based Nanobiosensors as an Emerging Platform for Detection of Disease

Abu‐Salah

Zourob

Mouffouk

et al. 2015

Sensors

109

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Detection of disease at an early stage is one of the biggest challenges in medicine. Different disciplines of science are working together in this regard. The goal of nanodiagnostics is to provide more accurate tools for earlier diagnosis, to reduce cost and to simplify healthcare delivery of effective and personalized medicine, especially with regard to chronic diseases (e.g., diabetes and cardiovascular diseases) that have high healthcare costs. Up-to-date results suggest that DNA-based nanobiosensors could be used effectively to provide simple, fast, cost-effective, sensitive and specific detection of some genetic, cancer, and infectious diseases. In addition, they could potentially be used as a platform to detect immunodeficiency, and neurological and other diseases. This review examines different types of DNA-based nanobiosensors, the basic principles upon which they are based and their advantages and potential in diagnosis of acute and chronic diseases. We discuss recent trends and applications of new strategies for DNA-based nanobiosensors, and emphasize the challenges in translating basic research to the clinical laboratory.

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Recent advances in fiber-optic DNA biosensors

Cited by 14 publications

References 62 publications

Kinetic study for the hybridization of 25-mer DNA by nonadiabatic tapered optical fiber sensor

Kinetic study for the hybridization of 25-mer DNA by nonadiabatic tapered optical fiber sensor

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

DNA-Based Nanobiosensors as an Emerging Platform for Detection of Disease

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