Recent advances in endocrine organoids for therapeutic application

Jeon, Suwan; Lee, Y S; Oh, Sewon; Jeong, Jinseong; Lee, Dong-Hyun; So, Kyoung-Ha; Hwang, Nathaniel S.

doi:10.1016/j.addr.2023.114959

Cited by 5 publications

(3 citation statements)

References 234 publications

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“…Due to its complexity, understanding and treating endocrine diseases have been a challenge. However, the emergence of endocrine organoids has opened up the possibility of repairing tissue damage after transplantation [ 38 ].…”

Section: Engineering Organoids With Applications In Tissue Repair And...mentioning

confidence: 99%

“…Applying bioengineering principles to organoids can enhance reproducibility, ensure experimental controllability, improve culture efficiency, optimize the tissue structure and physiological function of organoids, and pave the way for the clinical translation of organoids. Engineered organoids can be used to treat injuries caused by most factors, including various disease types affecting the brain [ 33 ], skin [ 34 ], bone and cartilage [ 35 , 36 ], liver [ 37 ], and endocrine glands [ 38 ]. Moreover, organoid engineering approaches have been successfully applied to organoid construction to achieve tissue repair and biofunction reconstruction.…”

Section: Introductionmentioning

confidence: 99%

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Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction

Jin,

Xue,

Liu

et al. 2024

Biomater Res

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Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models and in drug discovery and screening. Indeed, several studies have shown that organoids are an important strategy for achieving tissue repair and biofunction reconstruction. In contrast to established stem cell therapies, organoids have high clinical relevance. However, conventional approaches have limited the application of organoids in clinical regenerative medicine. Engineered organoids might have the capacity to overcome these challenges. Bioengineering—a multidisciplinary field that applies engineering principles to biomedicine—has bridged the gap between engineering and medicine to promote human health. More specifically, bioengineering principles have been applied to organoids to accelerate their clinical translation. In this review, beginning with the basic concepts of organoids, we describe strategies for cultivating engineered organoids and discuss the multiple engineering modes to create conditions for breakthroughs in organoid research. Subsequently, studies on the application of engineered organoids in biofunction reconstruction and tissue repair are presented. Finally, we highlight the limitations and challenges hindering the utilization of engineered organoids in clinical applications. Future research will focus on cultivating engineered organoids using advanced bioengineering tools for personalized tissue repair and biofunction reconstruction.

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Section: Engineering Organoids With Applications In Tissue Repair And...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction

Jin,

Xue,

Liu

et al. 2024

Biomater Res

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“…Research on stem cell-derived tissues and organoids is rapidly expanding, providing not only fascinating insights into basic principles of morphogenesis but also taking steps towards practical applications in drug discovery and toxicity testing, as well as tissue and organ replacements in humans [1][2][3][4][5][6][7][8][9]. Recently, the technically closely related creation of complex embryoids has excited vivid discussions, particularly regarding ethical questions [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Stem Cell-Derived Organoids, Embryoids, and Embryos: Advances in Organismic Development In Vitro Force Us to Re-Focus on Ethical and Legal Aspects of Model Choice

Denker

2023

Organoids

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While research on stem cell-derived tissues and organoids is rapidly expanding, the technically related creation of complex embryoids has recently excited a vivid discussion since it raises ethical questions about individuation and the possible gain of viability. The present study focuses on the onset of organismic development and the proposed biological and legal definitions for the terms embryo, embryoid, and organoid. It is concluded that such considerations have become important for investigators’ choices of the appropriate in vitro model systems, allowing the formation of organoids vs. complex embryoids.

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