Recent Advances in Electrospun Sustainable Composites for Biomedical, Environmental, Energy, and Packaging Applications

Líu, Hao; Gough, Christopher R.; Deng, Qianqian; Gu, Zhenggui; Wang, Fang; Hu, Xiao

doi:10.3390/ijms21114019

Cited by 55 publications

(43 citation statements)

References 155 publications

(228 reference statements)

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“…In order to overcome this, several samples of zein-citrate solutions were prepared and spun in sequential order on a day with low humidity; ideally, the humidity should be below 20% to allow the solvent to evaporate off during the spinning process. Note, however, that electrospinning is also hindered by high humidity [55]. Solutions could not be prepared in advance, as this would cause solutions to become too viscous to air-spray.…”

Section: Reflection and Future Considerationsmentioning

confidence: 99%

Air-Jet Spun Corn Zein Nanofibers and Thin Films with Topical Drug for Medical Applications

Gough

Bessette

Xue

et al. 2020

IJMS

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Diabetic patients are especially susceptible to chronic wounds of the skin, which can lead to serious complications. Sodium citrate is one potential therapeutic molecule for the topical treatment of diabetic ulcers, but its viability requires the assistance of a biomaterial matrix. In this study, nanofibers and thin films fabricated from natural corn zein protein are explored as a drug delivery vehicle for the topical drug delivery of sodium citrate. Corn zein is cheap and abundant in nature, and easily extracted with high purity, while nanofibers are frequently cited as ideal drug carriers due to their high surface area and high porosity. To further reduce costs, the 1-D nanofibers in this study were fabricated through an air jet-spinning method rather than the conventional electrospinning method. Thin films were also created as a comparative 2-D material. Corn zein composite nanofibers and thin films with different concentration of sodium citrate (1–30%) were analyzed through FTIR, DSC, TGA, and SEM. Results reveal that nanofibers are a much more effective vehicle than films, with the ability to interact with sodium citrate. Thermal analysis results show a stable material with low degradation, while FTIR reveals strong control over the protein secondary structures and hold of citrate. These tunable properties and morphologies allow the fibers to provide a sustained release of citrate and then revert to their structure prior to citrate loading. A statistical analysis via t-test confirmed a significant difference between fiber and film drug release. A biocompatibility study also confirms that cells are much more tolerant of the porous nanofiber structure than the nonporous protein films, and lower percentages of sodium citrate (1–5%) were outperformed to higher percentages (15–30%). This study demonstrated that protein-based nanofiber materials have high potential as vehicles for the delivery of topical diabetic drugs.

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Section: Reflection and Future Considerationsmentioning

confidence: 99%

Air-Jet Spun Corn Zein Nanofibers and Thin Films with Topical Drug for Medical Applications

Gough

Bessette

Xue

et al. 2020

IJMS

Self Cite

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“…Electrospinning allows exceptional versatility to produce fiber scaffolds with targeted properties [ 1 ]. Varying some electrospinning parameters, features of the morphology can be enhanced, resulting in better mechanical properties [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Mechanical Properties of Electrospun Polycaprolactone Scaffolds: Effect of Applied Voltage

et al. 2021

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The aim of this work is to investigate the effect of the applied voltage on the morphological and mechanical properties of electrospun polycaprolactone (PCL) scaffolds for potential use in tissue engineering. The morphology of the scaffolds was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and the BET techniques for measuring the surface area and pore volume. Stress-strain curves from tensile tests were obtained for estimating the mechanical properties. Additional studies for detecting changes in the chemical structure of the electrospun PCL scaffolds by Fourier transform infrared were performed, while contact angle and X-ray diffraction analysis were realized for determining the wettability and crystallinity, respectively. The SEM, AFM and BET results demonstrate that the electrospun PCL fibers exhibit morphological changes with the applied voltage. By increasing the applied voltage (10 to 25 kV) a significate influence was observed on the fiber diameter, surface roughness, and pore volume. In addition, tensile strength, elongation, and elastic modulus increase with the applied voltage, the crystalline structure of the fibers remains constant, and the surface area and wetting of the scaffolds diminish. The morphological and mechanical properties show a clear correlation with the applied voltage and can be of great relevance for tissue engineering.

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“…The electrospun nanofibers’ properties such as morphology and diameter are influenced by intrinsic (solution properties) and extrinsic (process and environment) factors [ 202 , 203 , 204 ]. Dorati et al [ 205 ] reported that solvent concentration, viscosity, electrical conductivity, and elasticity are the most influential parameters on the geometry and morphology of electrospun nanofibers.…”

Section: Current Progress On Elaboration Process Implementation mentioning

confidence: 99%

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

et al. 2021

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Over the last twenty years, researchers have focused on the potential applications of electrospinning, especially its scalability and versatility. Specifically, electrospun nanofiber scaffolds are considered an emergent technology and a promising approach that can be applied to biosensing, drug delivery, soft and hard tissue repair and regeneration, and wound healing. Several parameters control the functional scaffolds, such as fiber geometrical characteristics and alignment, architecture, etc. As it is based on nanotechnology, the concept of this approach has shown a strong evolution in terms of the forms of the materials used (aerogels, microspheres, etc.), the incorporated microorganisms used to treat diseases (cells, proteins, nuclei acids, etc.), and the manufacturing process in relation to the control of adhesion, proliferation, and differentiation of the mimetic nanofibers. However, several difficulties are still considered as huge challenges for scientists to overcome in relation to scaffolds design and properties (hydrophilicity, biodegradability, and biocompatibility) but also in relation to transferring biological nanofibers products into practical industrial use by way of a highly efficient bio-solution. In this article, the authors review current progress in the materials and processes used by the electrospinning technique to develop novel fibrous scaffolds with suitable design and that more closely mimic structure. A specific interest will be given to the use of this approach as an emergent technology for the treatment of bacteria and viruses such as COVID-19.

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Recent Advances in Electrospun Sustainable Composites for Biomedical, Environmental, Energy, and Packaging Applications

Cited by 55 publications

References 155 publications

Air-Jet Spun Corn Zein Nanofibers and Thin Films with Topical Drug for Medical Applications

Air-Jet Spun Corn Zein Nanofibers and Thin Films with Topical Drug for Medical Applications

Morphological and Mechanical Properties of Electrospun Polycaprolactone Scaffolds: Effect of Applied Voltage

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

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