Recent advances in electrochemical non-enzymatic glucose sensors – A review

Hwang, Dae-Woong; Lee, Saram; Seo, Mi Hae; Chung, Taek Dong

doi:10.1016/j.aca.2018.05.051

Cited by 632 publications

(373 citation statements)

References 334 publications

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“…Typically, electrochemical sensors are considered as an auspicious choice for the controlled and effective monitoring of glucose . In general, based on the mode of functionality and electrode material, the electrochemical sensors can be categorized into enzymatic and non‐enzymatic systems . The enzyme‐based glucose biosensors are considered as reliable and authentic systems for highly sensitive and selective detection of glucose in human blood and other body fluids .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

et al. 2020

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Mixed metals alloy nanoparticles supported on carbon nanomaterial are the most attractive candidates for the fabrication of non‐enzymatic electrochemical sensor with enhanced electrochemical performance. In this study, palladium‐manganese alloy nanoparticles supported on reduced graphene oxide (Pd−Mn/rGO) are prepared by a simple reduction protocol. Further, a novel enzyme‐free glucose sensing platform is established based on Pd−Mn/rGO. The successful fabrication of Pd−Mn alloy nanoparticles and their attachment at rGO are thoroughly characterized by various microscopic and spectroscopic techniques such as XRD, Raman, TEM and XPS. The electrochemical activity and sensing features of designed material towards glucose detection are explored by amperometric measurments in 0.1 M NaOH at the working voltage of −0.1 V. Thanks to the newly designed Pd−Mn/rGO nanohybrid for their superior electrorochemical activity towards glucose comprising the admirable sensing features in terms of targeted selectivity, senstivity, two linear parts and good stability. The enhanced electrochemical efficacy of Pd−Mn/rGO electrocatalyst may be credited to the abundant elecrocatalytic active sites formed during the Pd−Mn alloying and the electron transport ability of rGO that augment the electron shuttling phenomenon between the electrode material and targeted analyte.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

et al. 2020

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“…While a non-enzymatic glucose sensor demonstrates many benefits; their measurement range is limited to up to several mmol/L(mM), which is much smaller than the blood glucose level of diabetic patients (1-30 mM) [12,13]. During glucose sensing, the current response first enters a linear range where a linear relationship between the current response and glucose concentration can be expected [14,15]. Next, a non-linear relationship is observed, dubbed non-linear range, during which the relationship between the current response and glucose concentration is unpredictable.…”

Section: Introductionmentioning

confidence: 99%

“…Although the current could increase along with the glucose level in the range between the linear range and the saturation, i.e., non-linear range, such a range is not useful as the saturation is not fixed. Therefore, the glucose concentration can only be extracted by the current response in the linear range, which leaves the challenge of raising the linear range [14].…”

Section: Introductionmentioning

confidence: 99%

Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH− Concentration

Yang

Liu

et al. 2020

Crystals

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The linear range of the non-enzymatic glucose sensor is usually much smaller than the glucose level of diabetic patients, calling for an effective solution. Despite many previous attempts, none have solved the problem. Such a challenge has now been conquered by raising the NaOH concentration in the electrolyte, where amperometry, X-ray diffraction, Fourier-transform infrared spectroscopy, and Nuclear magnetic resonance measurements have been conducted. The linear range has been successfully enhanced to 40 mM in 1000 mM NaOH solution, and it was also found that NaOH affected the degree of glucose oxidation, which influenced the current response during sensing. It was expected that the alkaline concentration must be 25 times higher than the glucose concentration to enhance the linear range, much contrary to prior understanding.

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“…The non-enzymatic detection of glucose is a more recent alternative, based on carbon, Au or indium tin oxide (ITO) electrodes that are modified with multiwalled carbon nanotubes (MWCNT), Pd, Pt, Au, transition metals and metal oxides etc. [47].…”

Section: Introductionmentioning

confidence: 99%

Progress in Electrochemical (Bio)Sensors for Monitoring Wine Production

et al. 2019

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Electrochemical sensors and biosensors have been proposed as fast and cost effective analytical tools, meeting the robustness and performance requirements for industrial process monitoring. In wine production, electrochemical biosensors have proven useful for monitoring critical parameters related to alcoholic fermentation (AF), malolactic fermentation (MLF), determining the impact of the various technological steps and treatments on wine quality, or assessing the differences due to wine age, grape variety, vineyard or geographical region. This review summarizes the current information on the voltamperometric biosensors developed for monitoring wine production with a focus on sensing concepts tested in industry-like settings and on the main quality parameters such as glucose, alcohol, malic and lactic acids, phenolic compounds and allergens. Recent progress featuring nanomaterial-enabled enhancement of sensor performance and applications based on screen-printed electrodes is emphasized. A case study presents the monitoring of alcoholic fermentation based on commercial biosensors adapted with minimal method development for the detection of glucose and phenolic compounds in wine and included in an automated monitoring system. The current challenges and perspectives for the wider application of electrochemical sensors in monitoring industrial processes such as wine production are discussed.

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Recent advances in electrochemical non-enzymatic glucose sensors – A review

Cited by 632 publications

References 334 publications

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

Fabrication of Non‐enzymatic Electrochemical Glucose Sensor Based on Pd−Mn Alloy Nanoparticles Supported on Reduced Graphene Oxide

Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH− Concentration

Progress in Electrochemical (Bio)Sensors for Monitoring Wine Production

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