Recent advances in electrochemical nanomaterial-based aptasensors for the detection of cancer biomarkers

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarker Detection: A Review

“…Aptamers are single stranded nucleotides (ssDNA or ssRNA) synthesized through systematic evolution of ligands by exponential enrichment (SELEX). With different sequences and 3D structures, they can specifically bind to various targets, such as small molecules, proteins, whole cells, and nucleotide sequences [ 146 ]. Aptamers are “chemical antibodies” that detect analytes based on conformational changes, which have the advantages of a small size, high chemical stability, high specificity, easy synthesis and modification, and low cost, etc., and which are widely used in the field of novel biosensing technologies in combination with numerous nanomaterials.…”

An electrochemical aptasensor based on Ce-MOF@COF to detect carcinoembryonic antigen

“…These targets include proteins, cells, small molecules, and even metal ions, some of which are difficult to target with antibodies. 28 In contrast to enzyme and antibody sensors, aptasensors are known for their ease of modification and low immunogenicity. 29 Simultaneously, aptamers can be synthesized in vitro at low cost and in large quantities, and can be easily modified with nanomaterials for target identification and detection.…”

Development of an aptasensor for highly sensitive detection of cardiac troponin I using cobalt–nickel metal-organic framework (CoNi-MOF)

“…Moreover, the customizable structural properties of MOFs allow for precise tailoring to meet specific biosensing requirements through the modification of organic ligands. This adaptability ensures improved stability and conductivity, maintaining consistent sensor performance across diverse environments, including physiological conditions, environmental hazards, and wearable sensors [ [17] , [18] , [19] , [20] , [21] , [22] , [23] ].…”