Recent advances in digital Positron Emission Tomography

Abstract

A: Positron Emission Tomography (PET) is a non-disruptive functional imaging technique, which provides a high resolution and high-sensitivity measurement of the functional processes in biological systems. The recent developments in biology and radio-chemistry enabled PET to study an increasing number of functional processes, but became highly demanding in terms of sensitivity, spatial resolution, and adaptability to the variable size of the biological systems ranging from few millimeters up to several centimeters. In this paper we show how digital signal processing in PET plays an important role in the technological advancement. We report the recent results of digital signal processing methods based on the Multi Voltage Threshold technology, exploring the performances of a series of digital PET systems built upon this principle. We further describe developments of the MVT theory including space-pattern digital signal analysis and the related idea of the integration of the MVT technology within intelligent CMOS SiPM sensors for PET.

Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?

“…Finally, the brain of the mouse was segmented with a threshold-based algorithm by using the standardized uptake value (SUV) of the PET image, followed by a topological closure. The segmented brain images were co-registered with a mouse brain atlas (Ma et al, 2005;D'Ascenzo et al, 2020) by using a mutual information method, and 19 brain regions were identified, as reported in Table 1. Finally, the SUV of each mouse was calculated both in the entire brain and in each of the segmented brain regions separately.…”