Recent advances in digital microfluidic chips for food safety analysis: Preparation, mechanism and application

Wang, Anyu; Feng, Xiao; He, Gang; Xiao, Ying; Zhong, Tian; Yu, Xi

doi:10.1016/j.tifs.2023.03.009

Cited by 18 publications

(4 citation statements)

References 85 publications

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“…[4] Over the years, the advancement of microfluidic chips has brought about a revolution in various fields, including material synthesis, [5,6] cell culture, [7,8] drug screening, [9,10] and substance analysis. [11][12][13][14] Particularly, microfluidic biosensors, dedicated to detecting and analyzing biomarkers in liquid samples, have emerged as a vibrant and extensively researched domain. The era of relying on large, expensive instruments that demand higher sample and reagent consumption, leading to poor portability and elevated analysis costs, is now obsolete.…”

Section: Introductionmentioning

confidence: 99%

“…In 1990, Manz et al., at Ciba‐Geigy Company in Switzerland pioneered microfluidic chip technology by utilizing microelectromechanical systems (MEMS) to etch micropipes in flat plates, culminating in the development of a capillary electrophoresis microchip analysis device [4] . Over the years, the advancement of microfluidic chips has brought about a revolution in various fields, including material synthesis, [5,6] cell culture, [7,8] drug screening, [9,10] and substance analysis [11–14] . Particularly, microfluidic biosensors, dedicated to detecting and analyzing biomarkers in liquid samples, have emerged as a vibrant and extensively researched domain.…”

Section: Introductionmentioning

confidence: 99%

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Applications of Metals and Metal Compounds in Improving the Sensitivity of Microfluidic Biosensors – A Review

Zhang,

Dong,

Gao

et al. 2024

Chemistry A European J

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The enhancement of detection sensitivity in microfluidic sensors has been a continuously explored field. Initially, many strategies for sensitivity improvement involved introducing enzyme cascade reactions, but enzyme‐based reactions posed challenges in terms of cost, stability, and storage. Therefore, there is an urgent need to explore enzyme‐free cascade amplification methods, which are crucial for expanding the application range and improving detection stability. Metal or metal compound nanomaterials have gained great attention in the exploitation of microfluidic sensors due to their ease of preparation, storage, and lower cost. The unique physical properties of metallic nanomaterials, including surface plasmon resonance, surface‐enhanced Raman scattering, metal‐enhanced fluorescence, and surface‐enhanced infrared absorption, contribute significantly to enhancing detection capabilities. The metal‐based catalytic nanomaterials, exemplified by Fe3O4 nanoparticles and metal‐organic frameworks, are considered viable alternatives to biological enzymes due to their excellent performance. Herein, we provide a detailed overview of the applications of metals and metal compounds in improving the sensitivity of microfluidic biosensors. This review not only highlights the current developments but also critically analyzes the challenges encountered in this field. Furthermore, it outlines potential directions for future research, contributing to the ongoing development of microfluidic biosensors with improved detection sensitivity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications of Metals and Metal Compounds in Improving the Sensitivity of Microfluidic Biosensors – A Review

Zhang,

Dong,

Gao

et al. 2024

Chemistry A European J

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“…Microfluidic sensors have the advantages of high throughput, miniaturization, portability, and small reagent consumption [35][36][37][38][39][40][41], which can rapidly obtain more accurate detection results. It is significant for food safety to develop on-site detection technologies and portable equipment [42][43][44]. Microfluidic sensors can identify specific analytes through biomolecules and enhance them into detectable signals [45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Advances in Microfluidics Techniques for Rapid Detection of Pesticide Residues in Food

Jiang

Guo

et al. 2023

Foods

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Food safety is a significant issue that affects people worldwide and is tied to their lives and health. The issue of pesticide residues in food is just one of many issues related to food safety, which leave residues in crops and are transferred through the food chain to human consumption. Foods contaminated with pesticide residues pose a serious risk to human health, including carcinogenicity, neurotoxicity, and endocrine disruption. Although traditional methods, including gas chromatography, high-performance liquid chromatography, chromatography, and mass spectrometry, can be used to achieve a quantitative analysis of pesticide residues, the disadvantages of these techniques, such as being time-consuming and costly and requiring specialist staff, limit their application. Therefore, there is a need to develop rapid, effective, and sensitive equipment for the quantitative analysis of pesticide residues in food. Microfluidics is rapidly emerging in a number of fields due to its outstanding strengths. This paper summarizes the application of microfluidic techniques to pyrethroid, carbamate, organochlorine, and organophosphate pesticides, as well as to commercial products. Meanwhile, the study also outlines the development of microfluidics in combination with 3D printing technology and nanomaterials for detecting pesticide residues in food.

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“…In response to the above-mentioned issues, in recent years, digital microfluidics technology has been applied in various fields such as food safety [23,24], medicine [25][26][27], and environmental monitoring [28,29], enabling multi-sample detection and even multiparameter detection. In order to achieve multi-channel detection of soil nitrate, digital microfluidics technology was introduced in this study.…”

Section: Introductionmentioning

confidence: 99%

Multi-Sample Detection of Soil Nitrate Nitrogen Using a Digital Microfluidic Platform

Hong,

Xia,

et al. 2023

Agriculture

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The rapid quantification of nitrate nitrogen concentration plays a pivotal role in monitoring soil nutrient content. Nevertheless, the low detection efficiency limits the application of traditional methods in rapid testing. For this investigation, we utilized a digital microfluidic platform and 3D-printed microfluidics to accomplish automated detection of soil nitrate nitrogen with high sensitivity across numerous samples. The system combines digital microfluidics (DMF), 3D-printed microfluidics, a peristaltic pump, and a spectrometer. The soil solution, obtained after extraction, was dispensed onto the digital microfluidic platform using a micropipette. The digital microfluidic platform regulated the movement of droplets until they reached the injection area, where they were then aspirated into the 3D-printed microfluidic device for absorbance detection. Implementing this approach allows for the convenient sequential testing of multi-samples, thereby enhancing the efficiency of nitrate nitrogen detection. The results demonstrate that the device exhibits rapid detection (200 s for three samples), low reagent consumption (40 µL per sample), and low detection limit (95 µg/L). In addition, the relative error between the detected concentration and the concentration measured by ultraviolet spectrophotometry is kept within 20%, and the relative standard deviation (RSD) of the measured soil samples is between 0.9% and 4.7%. In the foreseeable future, this device will play a significant role in improving the efficiency of soil nutrient detection and guiding fertilization practices.

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Recent advances in digital microfluidic chips for food safety analysis: Preparation, mechanism and application

Cited by 18 publications

References 85 publications

Applications of Metals and Metal Compounds in Improving the Sensitivity of Microfluidic Biosensors – A Review

Applications of Metals and Metal Compounds in Improving the Sensitivity of Microfluidic Biosensors – A Review

Advances in Microfluidics Techniques for Rapid Detection of Pesticide Residues in Food

Multi-Sample Detection of Soil Nitrate Nitrogen Using a Digital Microfluidic Platform

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