Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

Kaur, Jaskiran; Gulati, Monica; Jha, Niraj Kumar; Disouza, John; Patravale, Vandana; Dua, Kamal; Singh, Sachin Kumar

doi:10.1016/j.drudis.2022.02.005

Cited by 43 publications

(14 citation statements)

References 94 publications

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“…Further experiments verified that this system could inhibit the proliferation and migration of colon cancer cells and reverse the drug resistance of oxaliplatin [162]. Polymer nanoparticles have high biocompatibility and stability, which can improve the controlled release effect and solubility of drugs [163]. Dos Santos et al developed 5-Fu-loaded chitosan nanoparticles (CS NPs) and incorporated them into retrograded starch and pectin (RS/P) particles.…”

Section: Chemotherapymentioning

confidence: 99%

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Deng

Jiang

et al. 2022

J Nanobiotechnol

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Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that seriously threatens human health. Due to the unique organ structure of the gastrointestinal tract, endoscopic and MRI diagnoses of GIC in the clinic share the problem of low sensitivity. The ineffectiveness of drugs and high recurrence rates in surgical and drug therapies are the main factors that impact the curative effect in GIC patients. Therefore, there is an urgent need to improve diagnostic accuracies and treatment efficiencies. Nanotechnology is widely used in the diagnosis and treatment of GIC by virtue of its unique size advantages and extensive modifiability. In the diagnosis and treatment of clinical GIC, surface-enhanced Raman scattering (SERS) nanoparticles, electrochemical nanobiosensors and magnetic nanoparticles, intraoperative imaging nanoparticles, drug delivery systems and other multifunctional nanoparticles have successfully improved the diagnosis and treatment of GIC. It is important to further improve the coordinated development of nanotechnology and GIC diagnosis and treatment. Herein, starting from the clinical diagnosis and treatment of GIC, this review summarizes which nanotechnologies have been applied in clinical diagnosis and treatment of GIC in recent years, and which cannot be applied in clinical practice. We also point out which challenges must be overcome by nanotechnology in the development of the clinical diagnosis and treatment of GIC and discuss how to quickly and safely combine the latest nanotechnology developed in the laboratory with clinical applications. Finally, we hope that this review can provide valuable reference information for researchers who are conducting cross-research on GIC and nanotechnology.

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Section: Chemotherapymentioning

confidence: 99%

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Deng

Jiang

et al. 2022

J Nanobiotechnol

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“…Polymeric micelles represent drug delivery nanosystems that possess a core–shell structure and are created when amphiphilic block copolymers (ABCs) self-assemble in an aqueous solution [ 13 ]. Polymeric micelles also refer to systems where the lipophilic portion of the amphiphilic polymer is directed to the center of the micelles and the hydrophilic portion is directed outward.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

“…Polymeric micelles also refer to systems where the lipophilic portion of the amphiphilic polymer is directed to the center of the micelles and the hydrophilic portion is directed outward. The hydrophilic component of the amphiphilic polymer is directed toward the core in reverse micelles, while the lipophilic component is directed outwards [ 13 ]. In the case of reverse micelles, the lipophilic portion of the amphiphilic polymer is directed outward and the hydrophilic portion is directed toward the center.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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“…The hydrophobic inner core of the copolymer moves closer to aggregation and distances itself from water molecules above this concentration, forming polymeric micelles. The unique characteristics of micelles, such as nanoscale size, stimuli-responsive cargo release, structural flexibility, charge switching ability, and self-assembly, could overcome the drawbacks of the poor bioavailability of AG [ 86 , 87 ]. Yao and his team formulated AP extract into mPEG-PLA micelle.…”

Section: Advances In a Paniculata Nano-formulationsmentioning

confidence: 99%

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

2022

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Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal plants showed that A. paniculata extracts and its major diterpene lactones have promising anti-inflammatory, antidiabetic, antimalarial, anticancer, antifungal, antibacterial, antioxidant, and hypoglycemic activities. However, these active phytochemicals have poor water solubility and bioavailability when delivered in a conventional dosage form. These biological barriers can be mitigated if the extract or isolated compound are delivered as nanoparticles. This review discusses existing studies and marketed products of A. paniculata in solid, liquid, semi-solid, and gaseous dosage forms, either as an extract or isolated pure compounds, as well as their deficits in reaching maximum bioavailability. The pharmaceutics and pharmacological activity of A. paniculata as a nano-delivery system are also discussed.

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Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

Cited by 43 publications

References 94 publications

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

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