Recent advances in delivery systems of fucoxanthin

Yuan, Yongkai; Ma, Mengjie; Zhang, Shuaizhong

doi:10.1016/j.foodchem.2022.134685

Cited by 9 publications

(6 citation statements)

References 86 publications

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“…Moreover, Lykov et al [ 129 ] demonstrated no toxicity of a composition of fucoxanthin with particles of porous aluminum oxide with polydimethylsiloxane on mice splenocytes and thymocytes, both under short-term (24 h) and long-term (129 h) incubation. For more information on the pharmaco/toxicological profile of fucoxanthin and its delivery strategies, several recent reviews are available [ 119 , 130 , 131 , 132 , 133 ].…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

et al. 2023

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The search for novel sources of nutrients is among the basic goals for achievement of sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow in open ponds or photobioreactors, thus enabling profitable exploitation of aquatic resources. Microalgae, a huge taxon containing photosynthetic microorganisms living in freshwater, as well as in brackish and marine waters, typically unicellular and eukaryotic, include green algae (Chlorophyceae), red algae (Rhodophyceae), brown algae (Phaeophyceae) and diatoms (Bacillariophyceae). In recent decades, diatoms have been considered the most sustainable sources of nutrients for humans with respect to other microalgae. This review focuses on studies exploring their bio-pharmacological activities when relevant for human disease prevention and/or treatment. In addition, we considered diatoms and their extracts (or purified compounds) when relevant for specific nutraceutical applications.

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Section: Secondary Metabolitesmentioning

confidence: 99%

Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

et al. 2023

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“…57,58 Furthermore, the low bioaccessibility of fucoxanthin can be addressed by encapsulation with biopolymers or nanoparticles, including maltodextrin, gum arabic, and caseinate-stabilized zein particles, which not only enhance the thermal stability of fucoxanthin but also improve its intestinal absorption. 59,60 Thus, by further optimizing the chemical structure of fucoxanthin and refining formulation processes, fucoxanthin holds the potential for more extensive clinical trials in treating metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, diverse strategies have been developed to improve its absorption and stability. Fucoxanthin’s absorption rate can be increased by utilizing media with high solubility, such as fish oil, medium-chain triacylglycerols, oleic acid, and bovine serum albumin. , Furthermore, the low bioaccessibility of fucoxanthin can be addressed by encapsulation with biopolymers or nanoparticles, including maltodextrin, gum arabic, and caseinate-stabilized zein particles, which not only enhance the thermal stability of fucoxanthin but also improve its intestinal absorption. , Thus, by further optimizing the chemical structure of fucoxanthin and refining formulation processes, fucoxanthin holds the potential for more extensive clinical trials in treating metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanisms of Fucoxanthin in Alleviating Lipid Deposition in Metabolic Associated Fatty Liver Disease

Yang,

Li,

Yan

et al. 2024

J. Agric. Food Chem.

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Metabolic-associated fatty liver disease (MAFLD) is witnessing a global surge; however, it still lacks effective pharmacological interventions. Fucoxanthin, a natural bioactive metabolite derived from marine brown algae, exhibits promising pharmacological functions, particularly in ameliorating metabolic disorders. However, the mechanisms underlying its therapeutic efficacy in addressing MAFLD remain elusive. Our present findings indicated that fucoxanthin significantly alleviated palmitic acid (PA)-induced hepatic lipid deposition in vitro and obesity-induced hepatic steatosis in ob/ob mice. Moreover, at both the protein and transcriptional levels, fucoxanthin effectively increased the expression of PPARα and CPT1 (involved in fatty acid oxidation) and suppressed FASN and SREBP1c (associated with lipogenesis) in both PA-induced HepG2 cells and hepatic tissues in ob/ob mice. This modulation was accompanied by the activation of AMPK. The capacity of fucoxanthin to improve hepatic lipid deposition was significantly attenuated when utilizing the AMPK inhibitor or siRNA-mediated AMPK silencing. Mechanistically, fucoxanthin activates AMPK, subsequently regulating the KEAP1/Nrf2/ARE signaling pathway to exert antioxidative effects and stimulating the PGC1α/NRF1 axis to enhance mitochondrial biogenesis. These collective actions contribute to fucoxanthin's amelioration of hepatic steatosis induced by metabolic perturbations. These findings offer valuable insights into the prospective utilization of fucoxanthin as a therapeutic strategy for managing MAFLD.

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“…Heatmap analysis showed that some lipids were significantly upregulated in the Low/CK group, but most lipids were significantly downregulated in the High/CK group. Research showed that fucoxanthin exhibits effective resistance to external stress, ensuring normal cell growth and development, and it exerts a physiological effect on optimizing plant growth, development, and immunity [49]. In root tissues, fucoxanthin was upregulated 4.37-fold in the Low/CK group and downregulated 0.82-fold in the High/CK group.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Effects of Cadmium Stress on the Growth, Physiological Characteristics, and Metabolic Profiling of Rice (Oryza sativa L.) Using HPLC-QTOF/MS

Lan,

He,

Zhang

et al. 2023

Chemosensors

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Cadmium (Cd) pollution is an important environmental problem, as it is easily absorbed by plants and gradually accumulates in the human body through the food chain. This study aimed to elucidate the changes in the metabolic response of the rice cultivar “TanLiangYou215” under Cd stress. Rice was grown in soil culture at 0 (Control), 2 (Low group), and 10 (High group) mg/kg CdCl2 for 90 days. The ultrastructural, Cd content, antioxidant activity, and metabolic changes to the rice in different tissues were analyzed. Phenotypic characterization and ultrastructure showed that the rice roots and leaves were significantly damaged and plant growth was inhibited in the High group, while plant growth was promoted in the Low group. Overall, Cd showed a regularity of “low promotion and high inhibition”. Physiological indices revealed that rice was significantly affected by Cd stress. Compared to the Control, Cd stress resulted in higher antioxidant enzyme activities, and the Low group suffered less oxidative damage than the High group. Metabolomic studies revealed that Cd stress significantly altered the metabolic profiles of rice plants. Rice responded to Cd stress by upregulating amino acids and regulating related pathways, including alanine, aspartate and glutamate metabolism, and arginine and proline metabolism. The significant expression of flavonoids with antioxidant properties helped rice resist the oxidative damage caused by Cd accumulation in the root tissue; Cd stress significantly downregulated glycerophospholipid metabolism in the stem and leaf tissues, which affected the cellular activities in rice stem and leaf tissues. We investigated the effects of Cd stress on ultrastructure, antioxidant activity, and metabolic changes in different tissues of the rice variety TLY215. Moreover, the different tissues of TLY215 can regulate these metabolic pathways to resist Cd stress, which provides valuable insights into the response of TLY215 to different concentrations of Cd.

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Recent advances in delivery systems of fucoxanthin

Cited by 9 publications

References 86 publications

Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

Molecular Mechanisms of Fucoxanthin in Alleviating Lipid Deposition in Metabolic Associated Fatty Liver Disease

Assessing the Effects of Cadmium Stress on the Growth, Physiological Characteristics, and Metabolic Profiling of Rice (Oryza sativa L.) Using HPLC-QTOF/MS

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