“…This marked discrepancy between increased response rate, but failure to prolong survival, has been well recognized by Schein and Hoth (1 978), and separates colorectal cancer from most other malignancies. Furthermore, many later studies, using drug combinations similar to that of Moertel and Falkson, have failed to substantiate the initially promising results and have given response rates no greater than those for 5-FU alone (Kane et alii, 1978;Belt and Stephen, 1979;Kemeny et alii, 1979, Priestman, 1978Buroker et alii 1978a;Buroker et a h , 1978b). A further death knell to the early enthusiasm for increased response using combination chemotherapy has been the inability of Moertel to confirm his own earlier encouraging report.…”