Recent advances in Cu(II)/Cu(I)-MOFs based nano-platforms for developing new nano-medicines

Sun, Yujie; Jiang, Xiaodi; Liu, Yiwei; Liu, Dong; Chen, Chen; Lu, Chengyu; Zhuang, Shuze; Kumar, Abhinav; Liu, Jianqiang

doi:10.1016/j.jinorgbio.2021.111599

Cited by 41 publications

(20 citation statements)

References 151 publications

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“…MOFs have high porosity and large specific surface area, and the open metal sites have certain antibacterial capabilities [ 21 , 22 , 23 , 24 ]. In addition, due to their good biocompatibility, MOFs are candidates for loading drugs and metal particles [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials

Zheng

Chen

et al. 2022

Molecules

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Metal-organic frameworks (MOFs), which have become popular in recent years as excellent carriers of drugs and biomimetic materials, have provided new research ideas for fighting pathogenic bacterial infections. Although various antimicrobial metal ions can be added to MOFs with physical methods, such as impregnation, to inhibit bacterial multiplication, this is inefficient and has many problems, such as an uneven distribution of antimicrobial ions in the MOF and the need for the simultaneous addition of large doses of metal ions. Here, we report on the use of MIL-101(Fe)@Ag with efficient metal-ion release and strong antimicrobial efficiency for co-sterilization. Fe-based MIL-101(Fe) was synthesized, and then Ag+ was uniformly introduced into the MOF by the substitution of Ag+ for Fe3+. Scanning electron microscopy, powder X-ray diffraction (PXRD) Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to investigate the synthesized MIL-101(Fe)@Ag. The characteristic peaks of MIL-101(Fe) and silver ions could be clearly seen in the PXRD pattern. Comparing the diffraction peaks of the simulated PXRD patterns clearly showed that MIL-101(Fe) was successfully constructed and silver ions were successfully loaded into MIL-101(Fe) to synthesize an MOF with a bimetallic structure, that is, the target product MIL-101(Fe)@Ag. The antibacterial mechanism of the MOF material was also investigated. MIL-101(Fe)@Ag exhibited low cytotoxicity, so it has potential applications in the biological field. Overall, MIL-101(Fe)@Ag is an easily fabricated structurally engineered nanocomposite with broad-spectrum bactericidal activity.

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Section: Introductionmentioning

confidence: 99%

MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials

Zheng

Chen

et al. 2022

Molecules

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“…Similarly, MOFs containing these metal ions will also benefit from GSH consumption and improve PDT performance. Considering Cu (II)-based MOF can effectively remove endogenous GSH, 104 Tang’s group 105 constructed MOF-2 based on Cu (II) as the active center and the porphyrin ligand as the PS, which specifically bound and absorbed GSH by Cu (II) to directly decrease the intracellular GSH concentration and produced high levels of ROS for PDT under light conditions. Decreasing intracellular GSH synergistically produced higher ROS concentration and accelerated cell apoptosis, thus enhancing the antitumor efficiency of PDT.…”

Section: Active Mofsmentioning

confidence: 99%

Recent Progress of Metal-Organic Framework-Based Photodynamic Therapy for Cancer Treatment

Ye¹,

Zhao²,

Sun³

et al. 2022

IJN

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Photodynamic therapy (PDT), combining photosensitizers (PSs) and excitation light at a specific wavelength to produce toxic reactive oxygen species, has been a novel and promising approach to cancer treatment with non-invasiveness, spatial specificity, and minimal systemic toxicity, compared with conventional cancer treatment. Recently, numerous basic research and clinical research have demonstrated the potential of PDT in the treatment of a variety of malignant tumors, such as esophageal cancer, bladder cancer, and so on. Metal-organic framework (MOF) has been developed as a new type of nanomaterial with the advantages of high porosity, large specific surface area, adjustable pore size, and easy functionalization, which could serve as carriers to load PSs or increase the accumulation of PSs in target cells during PDT. Moreover, active MOFs have the potential to construct multifunctional systems, which are conducive to refining the tumor microenvironment (TME) and implementing combination therapy to improve PDT efficacy. Hence, a comprehensive and in-depth depiction of the whole scene of the recent development of MOFs-based PDT in cancer treatment is desirable. This review summarized the recent research strategies of MOFs-based PDT in antitumor therapy from the perspective of MOFs functions, including active MOFs, inactive MOFs, and their further combination therapies in clinical antitumor treatment. In addition, the bottlenecks and obstacles in the application of MOFs in PDT are also described.

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“…Several research papers reported the usage of these methods to prepare 2D porphyrin NMOF sheets for various applications [ 31 , 50 , 107 , 108 , 109 , 110 ]. Their use in theranostic increased exponentially.…”

Section: Porphyrin Mofs As Theranostic Agentsmentioning

confidence: 99%

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

2022

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Metal-Organic Frameworks (MOFs) are hybrid multifunctional platforms that have found remarkable applications in cancer treatment and diagnostics. Independently, these materials can be employed in cancer treatment as intelligent drug carriers in chemotherapy, photothermal therapy, and photodynamic therapy; conversely, MOFs can further be used as diagnostic tools in fluorescence imaging, magnetic resonance imaging, computed tomography imaging, and photoacoustic imaging. One essential property of these materials is their great ability to fine-tune their composition toward a specific application by way of a judicious choice of the starting building materials (metal nodes and organic ligands). Moreover, many advancements were made concerning the preparation of these materials, including the ability to downsize the crystallites yielding nanoporous porphyrin MOFs (NMOFs) which are of great interest for clinical treatment and diagnostic theranostic tools. The usage of porphyrins as ligands allows a high degree of multifunctionality. Historically these molecules are well known for their reactive oxygen species formation and strong fluorescence characteristics, and both have proved helpful in cancer treatment and diagnostic tools. The anticipation that porphyrins in MOFs could prompt the resulting materials to multifunctional theranostic platforms is a reality nowadays with a series of remarkable and ground-breaking reports available in the literature. This is particularly remarkable in the last five years, when the scientific community witnessed rapid development in porphyrin MOFs theranostic agents through the development of imaging technologies and treatment strategies for cancer. This manuscript reviews the most relevant recent results and achievements in this particular area of interest in MOF chemistry and application.

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Recent advances in Cu(II)/Cu(I)-MOFs based nano-platforms for developing new nano-medicines

Cited by 41 publications

References 151 publications

MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials

MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials

Recent Progress of Metal-Organic Framework-Based Photodynamic Therapy for Cancer Treatment

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

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