Recent Advances in Copper-Catalyzed N-O Cleavage Strategy

Abstract

NO bond cleavage is one of the most efficient and powerful strategies to introduce Nor O-functional groups into molecules in organic synthesis. Copper catalyst, as the abundant in earth and inexpensive advantages has been widely used to construct C-N and CO bond. Furthermore, NO bond cleavage has been successfully applied in the total synthesis of natural products and pharmaceuticals. The new development of copper-catalyzed NO bond cleavage and its application in the total synthesis of natural products and pharmaceuticals in recent years have been summarized.

Divergent copper-catalyzed syntheses of 3-carboxylpyrroles and 3-cyanofurans from O-acetyl oximes and β-ketoesters/nitriles

“…1 This group of substrates can be effectively activated by transition metals under mild conditions with chemo- and regioselectivity. 2 Copper represents a gentle, abundant, and inexpensive reaction mediator between oxime esters and a variety of components, forming the basis of a noteworthy arsenal of synthetic procedures, 3 including annulations. 2 c ,4 N–C–C and N–C–C–C synthons are commonly provided by oxime esters, facilitating the formation of medicinally important N-containing heterocyclic compounds.…”