Recent advances in colloidal nanocomposite design<i>via</i>heterogeneous polymerization techniques

Thickett, Stuart C.; Teo, Guo Hui

doi:10.1039/c9py00097f

Cited by 36 publications

(28 citation statements)

References 220 publications

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“…Such core-shell structures are beneficial to prevent leaching of potentially toxic core-ions while providing a chemically active surface for the decoration with biomolecules. Formation of hybrid nano-colloids can either be performed as post-synthetic encapsulation step after core NP formation or in situ during NP synthesis [50]. Alternatively, to spherical nanoparticles, multi-compositions comprised of two-dimensional structures, such as graphene oxide, and inorganic or organic nanoparticles have been developed based on their unique theranostic performance [51].…”

Section: Composite Npsmentioning

confidence: 99%

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

146

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Based on their tunable physicochemical properties and the possibility of producing cell-specific platforms through surface modification with functional biomolecules, nanoparticles (NPs) represent highly promising tools for biomedical applications. To improve their potential under physiological conditions and to enhance their cellular uptake, combinations with cell-penetrating peptides (CPPs) represent a valuable strategy. CPPs are often cationic peptide sequences that are able to translocate across biological membranes and to carry attached cargos inside cells and have thus been recognized as versatile tools for drug delivery. Nevertheless, the conjugation of CPP to NP surfaces is dependent on many properties from both individual components, and further insight into this complex interplay is needed to allow for the fabrication of highly stable but functional vectors. Since CPPs per se are nonselective and enter nearly all cells likewise, additional decoration of NPs with homing devices, such as tumor-homing peptides, enables the design of multifunctional platforms for the targeted delivery of chemotherapeutic drugs. In this review, we have updated the recent advances in the field of CPP-NPs, focusing on synthesis strategies, elucidating the influence of different physicochemical properties, as well as their application in cancer research.

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Section: Composite Npsmentioning

confidence: 99%

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

146

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“…Stable, small, and narrowly distributed droplets can be formed, and they can ideally retain their size and shape identical throughout the polymerization process. This enables the encapsulation of all kinds of different solid or liquid materials into polymer nanoparticles [ 27 ]. The synthesis of nano-capsules with a hydrophobic core in a hydrophobic shell is based on the principle of mini-emulsion that utilizes the differences of interfacial tensions and the phase separation process of the polymer and the hydrophobic component during polymerization [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of D-Limonene Loaded Polymeric Nanoparticles with Enhanced Antimicrobial Properties for Potential Application in Food Packaging

et al. 2021

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Mini-emulsion polymerization was applied for the synthesis of cross-linked polymeric nanoparticles comprised of methyl methacrylate (MMA) and Triethylene Glycol Dimethacrylate (TEGDMA) copolymers, used as matrix-carriers for hosting D-limonene. D-limonene was selected as a model essential oil, well known for its pleasant odor and its enhanced antimicrobial properties. The synthesized particles were assessed for their morphology and geometric characteristics by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM), which revealed the formation of particles with mean diameters at the nanoscale (D[3,2] = 0.135 μm), with a spherical shape, while the dried particles formed larger clusters of several microns (D[3,2] = 80.69 μm). The percentage of the loaded D-limonene was quantified by Thermogravimetric Analysis (TGA), complemented by Gas Chromatography-Mass Spectrometry analysis coupled with a pyrolysis unit (Py/GC-MS). The results showed that the volatiles emitted by the nanoparticles were composed mainly of D-limonene (10% w/w of dry particles). Particles subjected to higher temperatures tended to decompose. The mechanism that governs the release of D-limonene from the as-synthesized particles was studied by fitting mathematical models to the release data obtained by isothermal TGA analysis of the dry particles subjected to accelerated conditions. The analysis revealed a two-stage release of the volatiles, one governed by D-limonene release and the other governed by TEGDMA release. Finally, the antimicrobial potency of the D-limonene-loaded particles was demonstrated, indicating the successful synthesis of polymeric nanoparticles loaded with D-limonene, owing to enhanced antimicrobial properties. The overall performance of these nanoparticles renders them a promising candidate material for the formation of self-sterilized surfaces with enhanced antimicrobial activity and potential application in food packaging.

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“…Once the bubbles collapse, a highly localized energy burst is released that significantly increases the temperature and pressure at an extremely short time. In general, ultrasound-based irradiation is an excellent pathway for producing nanocomposites, such as dispersed magnetic nanoparticles in reduced graphene oxides or magnetic nanoparticle-loaded latex beads [40]. Even though the sonolysis or sonochemical method are promising for the fabrication of magnetic nanoparticles with desired sizes and excellent magnetic saturation properties, this method suffers from the dispersity and controllability of the magnetic nanoparticles' shapes.…”

Section: Sonolysis or Sonochemical Methodsmentioning

confidence: 99%

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

Kouhpanji

Stadler

2020

Sensors

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The remarkable multimodal functionalities of magnetic nanoparticles, conferred by their size and morphology, are very important in resolving challenges slowing the progression of nanobiotechnology. The rapid and revolutionary expansion of magnetic nanoparticles in nanobiotechnology, especially in nanomedicine and therapeutics, demands an overview of the current state of the art for synthesizing and characterizing magnetic nanoparticles. In this review, we explain the synthesis routes for tailoring the size, morphology, composition, and magnetic properties of the magnetic nanoparticles. The pros and cons of the most popularly used characterization techniques for determining the aforementioned parameters, with particular focus on nanomedicine and biosensing applications, are discussed. Moreover, we provide numerous biomedical applications and highlight their challenges and requirements that must be met using the magnetic nanoparticles to achieve the most effective outcomes. Finally, we conclude this review by providing an insight towards resolving the persisting challenges and the future directions. This review should be an excellent source of information for beginners in this field who are looking for a groundbreaking start but they have been overwhelmed by the volume of literature.

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Recent advances in colloidal nanocomposite designviaheterogeneous polymerization techniques

Abstract: Recent advances in colloidal nanocomposite design by heterogeneous polymerization are reviewed, with a specific focus on encapsulation and particle-based stabilization for specific materials applications.

Cited by 36 publications

References 220 publications

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Synthesis of D-Limonene Loaded Polymeric Nanoparticles with Enhanced Antimicrobial Properties for Potential Application in Food Packaging

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

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