Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review

Ibrahim, Adel Ehab; Gohary, Nesrine Abdelrehim El; Aboushady, Dina; Samir, Liza; Karim, Shereen E. Abdel; Herz, Magy; Salman, Baher I.; Al‐Harrasi, Ahmed; Hanafi, Rasha S.; Deeb, Sami El

doi:10.1016/j.chroma.2023.464214

Cited by 7 publications

(3 citation statements)

References 331 publications

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“…Contrarily, HPLC offers a superior resolution, high sensitivity, broad applicability, and compatibility with a range of detection techniques. It is crucial for checking the validity, pharmacokinetics, and pharmacodynamics of chiral drugs at various stages of the drug development process [13].…”

Section: Importance Of Chiral Separationmentioning

confidence: 99%

“…The application of CDs in waterbased, polar organic, and polar buffers can result in a variety of selectivity. For chiral recognition, for instance, the nonaqueous system provides ion-pair critical interactions [13]. Aside from being commercially available in a variety of native and derivatized forms, cyclodextrins (CDs) have also been demonstrated to be broad-spectrum chiral selectors due to their UV transparency, durability, and broad enantiorecognition capabilities.…”

Section: Ce For Chiral Drugs Analysismentioning

confidence: 99%

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Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Al-Sulaimi,

Kushwah,

Abdullah Alsibani

et al. 2023

Molecules

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Chiral separation, the process of isolating enantiomers from a racemic mixture, holds paramount importance in diverse scientific disciplines. Using chiral separation methods like chromatography and electrophoresis, enantiomers can be isolated and characterized. This study emphasizes the significance of chiral separation in drug development, quality control, environmental analysis, and chemical synthesis, facilitating improved therapeutic outcomes, regulatory compliance, and enhanced industrial processes. Capillary electrophoresis (CE) has emerged as a powerful technique for the analysis of chiral drugs. This review also highlights the significance of CE in chiral drug analysis, emphasizing its high separation efficiency, rapid analysis times, and compatibility with other detection techniques. High-performance liquid chromatography (HPLC) has become a vital technique for chiral drugs analysis. Through the utilization of a chiral stationary phase, HPLC separates enantiomers based on their differential interactions, allowing for the quantification of individual enantiomeric concentrations. This study also emphasizes the significance of HPLC in chiral drug analysis, highlighting its excellent resolution, sensitivity, and applicability. The resolution and enantiomeric analysis of nonsteroidal anti-inflammatory drugs (NSAIDs) hold great importance due to their chiral nature and potential variations in pharmacological effects. Several studies have emphasized the significance of resolving and analyzing the enantiomers of NSAIDs. Enantiomeric analysis provides critical insights into the pharmacokinetics, pharmacodynamics, and potential interactions of NSAIDs, aiding in drug design, optimization, and personalized medicine for improved therapeutic outcomes and patient safety. Microfluidics systems have revolutionized chiral separation, offering miniaturization, precise fluid control, and high throughput. Integration of microscale channels and techniques provides a promising platform for on-chip chiral analysis in pharmaceuticals and analytical chemistry. Their applications in techniques such as high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) offer improved resolution and faster analysis times, making them valuable tools for enantiomeric analysis in pharmaceutical, environmental, and biomedical research.

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Section: Importance Of Chiral Separationmentioning

confidence: 99%

Section: Ce For Chiral Drugs Analysismentioning

confidence: 99%

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Al-Sulaimi,

Kushwah,

Abdullah Alsibani

et al. 2023

Molecules

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show abstract

“…Chromatographic and electromigration methods are most commonly used for enantioselective determinations. [ 18–23 ] A desirable approach to determining individual enantiomers of a given compound is using various types of sensors. The basis of chiral sensors is the so‐called chiral selectors, whose role is to selectively interact with a given enantiomer, expressed as the difference in the value of the measured signal.…”

Section: Introductionmentioning

confidence: 99%

Thiolated Chiral Naphthalene Diimide Derivatives as Effective Selectors of the β‐Blocker Atenolol Enantiomers

Kowalczyk,

Duszczyk,

Sęk

et al. 2024

Adv Funct Materials

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Atenolol β‐blocker drug (ATN) to treat hypertension and cardiovascular disorders such as angina pectoris is manufactured commercially in a racemic form, while only its (S)‐enantiomer shows selective β1‐blocking activity. Here, a new axially chiral thiolated naphthalene diimide derivatives (HS‐BIN‐NDI) for the rapid, simple, and sensitive detection of ATN enantiomers is presented. The Surface Plasmon Resonance (SPR) and Atomic Force Microscopy (AFM) experiments show that interactions between a chiral selector and a chiral analyte occur only when their configurations are opposite. The extensive computational simulations support this finding. The association coefficient determined by SPR is high (105‐106 M−1 s−1) and indicates that the interactions are electrostatic. The analytical utility of atropisomeric HS‐BIN‐NDIs is proven, and the voltammetric sensors designed to determine ATN enantiomers are constructed. The developed sensors are characterized by a wide analytical operating range from 5.0·10−3 to 1.0 µm, nanomolar detection limit, high selectivity, and a long lifetime. Several additives like urea, creatinine, glucose, human albumin, and hemoglobin do not affect ATN sensing.

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Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review

Vallamkonda,

Sethi,

Satti

et al. 2024

Chirality

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Chirality plays a crucial role in the drug development process, influencing fundamental chemical and biochemical processes and significantly affecting our daily lives. This review provides a comprehensive examination of mass spectrometric (MS) methods for the enantiomeric analysis of chiral drugs. It thoroughly investigates MS‐hyphenated techniques, emphasizing their critical role in achieving enantioselective analysis. Furthermore, it delves into the intricate chiral recognition mechanisms inherent in MS, elucidating the fundamental principles that govern successful chiral separations. By critically assessing the obstacles and potential benefits associated with each MS‐based method, this review offers valuable insights for researchers navigating the complexities of chiral analysis. Both qualitative and quantitative approaches are explored, presenting a comparative analysis of their strengths and limitations. This review is aimed at significantly enhancing the understanding of chiral MS methods, serving as a crucial resource for researchers and practitioners engaged in enantioselective studies.

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Recent advances in chiral selectors immobilization and chiral mobile phase additives in liquid chromatographic enantio-separations: A review

Cited by 7 publications

References 331 publications

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Emerging Developments in Separation Techniques and Analysis of Chiral Pharmaceuticals

Thiolated Chiral Naphthalene Diimide Derivatives as Effective Selectors of the β‐Blocker Atenolol Enantiomers

Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review

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