Recent Advances in Chemically Engineered Nanostructures Impact on Ischemic Stroke Treatment

Sri Kanaka Durga Vijayalakshmi, Gudivaka; Puvvada, Nagaprasad

doi:10.1021/acsomega.3c06228

Cited by 3 publications

(3 citation statements)

References 109 publications

(268 reference statements)

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“… 208 Inorganic non-metallic nanoparticles such as carbon nanotubes, graphene, and silica nanoparticles have been utilised for stroke treatment. 209 It is important to acknowledge that the majority of inorganic non-metallic compounds, excluding silica, have the capacity to be biotoxic, but silica has shown both biocompatibility and degradability. The brain has difficulty metabolising most inorganic non-metallic materials, leading to their accumulation.…”

Section: Limitation Of Nanoparticlesmentioning

confidence: 99%

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Wang,

Li,

Wang

et al. 2024

IJN

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Angiogenesis, or the formation of new blood vessels, is a natural defensive mechanism that aids in the restoration of oxygen and nutrition delivery to injured brain tissue after an ischemic stroke. Angiogenesis, by increasing vessel development, may maintain brain perfusion, enabling neuronal survival, brain plasticity, and neurologic recovery. Induction of angiogenesis and the formation of new vessels aid in neurorepair processes such as neurogenesis and synaptogenesis. Advanced nano drug delivery systems hold promise for treatment stroke by facilitating efficient transportation across the the blood-brain barrier and maintaining optimal drug concentrations. Nanoparticle has recently been shown to greatly boost angiogenesis and decrease vascular permeability, as well as improve neuroplasticity and neurological recovery after ischemic stroke. We describe current breakthroughs in the development of nanoparticle-based treatments for better angiogenesis therapy for ischemic stroke employing polymeric nanoparticles, liposomes, inorganic nanoparticles, and biomimetic nanoparticles in this study. We outline new nanoparticles in detail, review the hurdles and strategies for conveying nanoparticle to lesions, and demonstrate the most recent advances in nanoparticle in angiogenesis for stroke treatment.

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Section: Limitation Of Nanoparticlesmentioning

confidence: 99%

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Wang,

Li,

Wang

et al. 2024

IJN

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“…5,6 Nanostructured materials and nanomaterials are considered promising candidates for gas sensor design due to their large surface-to-volume ratio, numerous surface reactive sites, and tunable electronic/optical properties. 7,8 However, the applications of nanomaterials are often hindered by inherent toxicity, environmental instability, risks, sensitivity of uncontrolled surface defects to molecular adsorptions, complicated synthesis techniques, and challenges in achieving high-quality materials. 8,9 In this context, small molecules have recently attracted significant research interest for high-performance and costeffective optical and electrochemical gas sensor design.…”

Section: ■ Introductionmentioning

confidence: 99%

“…7,8 However, the applications of nanomaterials are often hindered by inherent toxicity, environmental instability, risks, sensitivity of uncontrolled surface defects to molecular adsorptions, complicated synthesis techniques, and challenges in achieving high-quality materials. 8,9 In this context, small molecules have recently attracted significant research interest for high-performance and costeffective optical and electrochemical gas sensor design. 10−12 Unlike nanomaterials, small molecular probes can be easily synthesized under mild conditions from low-cost precursor materials in a controlled manner.…”

Section: ■ Introductionmentioning

confidence: 99%

Comparative Analysis of the Hydrazine Interaction with Arylene Diimide Derivatives: Complementary Approach Using First Principles Calculation and Experimental Confirmation

Tiwari,

Fernandes,

Dey

et al. 2024

Langmuir

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Suitable functional group-engineered π-conjugated aromatic dimides based on perylene (PDI) and naphthyl scaffolds (NDI) demonstrated excellent sensitivity toward different gaseous analytes. However, to date, no methodical analysis has been performed to rationalize molecular-level interactions in the context of optical transduction, which is essential for systematic performance optimization of NDI/PDI-based molecular sensors. Therefore, in this present work, NDI/PDI scaffolds have been designed with amino acid functional groups (alanine, ALA and glutamic acid, GLU) at the terminal positions, and we subsequently compared the efficacy of four different imide derivatives as model hosts for hydrazine adsorption. Specifically, the adsorption of hydrazine at different interaction sites has been thoroughly investigated using ab initio calculations, where the adsorption energy, charge transfer, and recovery time have been emphasized. Theoretical results exhibit that irrespective of host specification the COOH groups offer a primary interaction site for hydrazine through the hydrogen bonding interaction. The presence of more COOH groups and relatively stronger interaction with secondary edge oxygen ensure that GLU functional moieties are a superior choice over ALU for efficient hydrazine binding. The molecular energy spectrum analysis exhibits more favorable HOMO/LUMO gap variations after hydrazine interaction in the case of PDI derivatives irrespective to the nature of the amino acid residues. Therefore, by a combination of both factors, PDI-GLU has been identified as the most suitable host molecule for hydrazine among four derivatives. Finally, the key theoretical predictions has been later experimentally validated by analyzing UV–visible spectroscopy and NMR studies, wherein the mechanism of interaction has also been experimentally verified by EPR analysis and FT-IR studies.

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Rhodamine-Based Electrospun Polyacrylonitrile (PAN) Nanofiber Sensor for the Detection of Chlorinated Hydrocarbon Vapors

Capan,

Bayrakci

2024

ACS Appl. Polym. Mater.

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This study is the first report on the fabrication of polyacrylonitrile (PAN) nanofiber with rhodamine-based chemosensor (RHE) onto a mass-sensitive quartz crystal substrate using the electrospinning method and its sensing capability toward chlorinated hydrocarbons. Fabricated nanofiber webs via the electrospinning process are characterized by Fourier Transform Infrared (FTIR-ATR), Scanning Electron Microscopy, and Contact Angle measurement techniques, respectively. In order to investigate the vapor sensor properties, a Quartz Crystal Microbalance (QCM) system is employed to collect the real-time experimental data when the nanofiber sensor PAN-RHE is exposed to chlorinated hydrocarbons. Pseudo first-order and Elovich models are applied to elucidate the adsorption behavior. The morphological characterization proved smooth surface morphology without bead formation for all fibers with uniformity in the fiber skeleton. The average diameters of neat PAN and PAN nanofibers with RHE are found to be 449 and 790 nm, respectively. The nanofiber sensor PAN-RHE exhibits excellent sensing characteristics, including a high sensitivity of 0.0276 Hz/ppm, response and recovery times of 2−3 and 5−7 s, respectively, high selectivity for chloroform compared to other vapors tested, a limit of detection (LOD) of about 119.56 ppm, and a limit of quantification (LOQ) of about 362.31 ppm with a good reproducibility. The Pseudo-first-order adsorption rate and the Elovich desorption constants are determined as a function of different concentrations. The results obtained suggest that the QCM-based nanofiber sensor PAN-RHE shows great potential for the design of highly sensitive and selective chloroform sensors.

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Recent Advances in Chemically Engineered Nanostructures Impact on Ischemic Stroke Treatment

Cited by 3 publications

References 109 publications

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Advances in Engineered Nanoparticles for the Treatment of Ischemic Stroke by Enhancing Angiogenesis

Comparative Analysis of the Hydrazine Interaction with Arylene Diimide Derivatives: Complementary Approach Using First Principles Calculation and Experimental Confirmation

Rhodamine-Based Electrospun Polyacrylonitrile (PAN) Nanofiber Sensor for the Detection of Chlorinated Hydrocarbon Vapors

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