Recent advances in chemical reactivity and biological activities of eugenol derivatives

Abdou, Achraf; Elmakssoudi, Abdelhakim; Amrani, Abdelaziz El; Jamaleddine, Jamal; Dakir, Mohamed

doi:10.1007/s00044-021-02712-x

Cited by 40 publications

(26 citation statements)

References 51 publications

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“…Fifty-four eugenol derivatives with various structures were retrieved from previously reported studies. [9,10,14,17,25] The ligands structures were drawn using Avogadro software [26] and subsequently their geometries were optimized under the MMFF94 force field with the steepest Descent algorithm. [27][28][29][30][31] Such optimization before starting docking is of great importance for avoiding structural defects for example, unsuitable bond lengths or bond angles which can affect the results accuracy.…”

Section: Ligand Preparationmentioning

confidence: 99%

“…Perry are their main natural sources, representing between 45 and 90% of the total oil. [ 10 ] Eugenol has wide applications in industrial products, in cosmetic, and food. Besides, it was found to exhibit significant biological activities, such as hypotensive, [ 11 ] antiparasitic, [ 12 ] antifungal, [ 13 ] antiviral, [ 14 ] anti‐inflammatory, [ 15 ] analgesic, [ 16 ] and anticarcinogenic [ 17 ] properties.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives

Nour

Abdou

Belaidi

et al. 2022

J Chinese Chemical Soc

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Cholinesterase enzymes are promising drug targets for the symptomatic treatment of Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine-degrading enzymes leads to improved neurocognitive function. The present work, attempted to identify eugenol derivatives possibly capable of inhibiting the acetylcholine enzymes, by implementing density functional theory (DFT), docking and molecular dynamics methods. The investigated compounds exhibited moderate to high affinity toward the target proteins with free binding energy values ranging from À6.3 to À11.5 kcal/mol. The best ligands in terms of binding energy were evaluated for their pharmacokinetic properties. Furthermore, molecular dynamics studies were performed to assess the stability under aqueous environment of ligands having shown good pharmacokinetic properties. The obtained results revealed that 4-alkyl-2-methoxyphenyl 3-bromobenzoate strongly tended to act as dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, leading to a good alternative for the treatment of AD. The highlighting of this study can be of great support for the Alzheimer treatment development.

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Section: Ligand Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives

Nour

Abdou

Belaidi

et al. 2022

J Chinese Chemical Soc

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“…52,53 Eugenol was originally known for its medicinal properties because of the properties of antimicrobial and antianimal toxin. 54 In recent years, it has attracted the attention of material chemists because of its special structure.…”

Section: Biomass Feedstock For Low-k Materialsmentioning

confidence: 99%

“…This compound is widely found in cloves and cinnamon in nature. It can be also obtained by the degradation of lignin. , Eugenol was originally known for its medicinal properties because of the properties of antimicrobial and antianimal toxin . In recent years, it has attracted the attention of material chemists because of its special structure.…”

Section: Biomass Feedstock For Low-k Materialsmentioning

confidence: 99%

Low-Dielectric Polymers Derived From Biomass

Hou

Fang

Huang

et al. 2021

ACS Appl. Polym. Mater.

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Biomass-derived high-performance polymers have recently received much attention because they are easily available and renewable. More recently, researchers have been interested in low-dielectric polymers derived from biomass feedstock. These polymers display good dielectric properties and high thermostability, as well as good mechanical properties, implying that they have potential application in microelectronic industry, especially in fifth-generation communication (5G). This review summarizes recent progress in low dielectric polymers based on the biomass, including the synthesis and properties of different types of biomass resins such as epoxy resins, benzoxazine resins, benzocyclobutene resins, perfluorocyclobutane resins, cyanate eaters, polyester resins, phthalonitrile resins, and a functional maleimide.

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“…It is worth noting that the expansive literature on the diverse chemical, pharmacological, and medical aspects of eugenol and clove oil have been periodically reviewed, [34][35][36] but research on the preparation of epoxy and thermosets and other materials from eugenol platform chemicals is much less discussed from the point of view of the synthesis of monomers based on eugenol molecules. 22 Consequently, enhancing and focusing on this theme will be timely, very useful, and important for the sustainable development of the field.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of eugenol‐based monomers for sustainable epoxy thermoplastic polymers

Kouznetsov

Méndez

2022

J of Applied Polymer Sci

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New developments in thermosets based on bioproducts are gaining significance due to the importance of replacing thermosets and their monomers, traditionally obtained from petrochemical processes, with biobased thermosets prepared from biomass. In the context of new BPA/DGEBA replacements with both enhanced performance and reduced toxicity and the development of innovative biobased thermosetting resins, the conversion of plant biomass, especially natural phenols, into useful polymeric materials is believed to have considerable environmental and economic value. Eugenols are receiving encouraging interest, not only due to their sourcing but also due to their structure and chemical properties, which could enhance the physical characteristics of thermosetting materials, and which could reduce their toxic effects on the environment and human health. The present review mainly focuses on the utilization of eugenol for the synthesis of biobased epoxy and its thermosetting resins, describing synthetic details of new designs for eugenol-based monomer and/or additive component preparation that are conducive to the formation of eugenol-containing polymeric materials. Synthetic methods for eugenol-based monomers are classified according to the principles of green chemistry and are divided into three large groups: single reactions, consecutive reactions, and multicomponent reactions. Outstanding physical characteristics of the formulated eugenol-based thermosetting epoxy materials are also described.

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Recent advances in chemical reactivity and biological activities of eugenol derivatives

Cited by 40 publications

References 51 publications

Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives

Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives

Low-Dielectric Polymers Derived From Biomass

Synthesis of eugenol‐based monomers for sustainable epoxy thermoplastic polymers

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