Recent advances in chemical functionalisation of graphene and sensing applications

Ijeomah, Geoffrey; Samsuri, Fahmi; Obite, Felix; Zawawi, Mohamad Adzhar Md

doi:10.1504/ijbnn.2020.107177

Cited by 2 publications

(1 citation statement)

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“…Since the discovery of graphene, GBMs have emerged and raised a growing interest. Their various properties such as mechanical strength and conductivity, still recently investigated, make these materials extremely promising and versatile. These properties encouraged the development of various GBM-based innovations such as water treatment .…”

Section: Introductionmentioning

confidence: 99%

Graphene-Based Materials In Vitro Toxicity and Their Structure–Activity Relationships: A Systematic Literature Review

Achawi

Pourchez

Feneon

et al. 2021

Chem. Res. Toxicol.

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The unique properties of graphene-based materials (GBMs) placed them among the most exciting nanomaterials of the past decade. Scientists and industrials are looking forward to working with not only performant, but also safe, sustainable GBMs. Designing a safer-by-design GBM implies to acquire the knowledge of which physicochemical characteristics (PCCs) can increase toxicity.In this systematic review, we extracted data from the literature to provide the available information about the structure-activity relationship of GBMs. 93 papers studying a total of 185 GBMs were included. Graphene oxides (GOs) and Few-layer graphenes (FLGs) are the most studied GBMs.While reduced graphene oxides (rGOs) were often classified as poorly oxidant and weakly cytotoxic, graphene quantum dots (GQDs) were mostly moderately or highly cytotoxic. FLGs demonstrated relationships between median size and oxidative stress, between lateral size and both cytotoxicity and oxidative stress and between thickness and cytotoxicity. We also underlined relationships between median size, lateral size and thickness of GOs and oxidative stress.However, it appeared difficult to highlight clear structure-activity relationships for most PCCs and biological endpoints because despite a large amount of available data, the GBMs are often too poorly characterized in terms of PCCs descriptors and the biological endpoints investigation is not standardized enough. There is an urgent need for a better standardization of the experimental investigation of both PCCs and biological endpoints to allow research teams to play a part in the collaborative work toward the construction of a safer-by-design GBM through a better understanding of their key toxicity drivers.

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Section: Introductionmentioning

confidence: 99%