Recent advances in cardiac biomarkers detection: From commercial devices to emerging technologies

Savonnet, Maud; Rolland, Tristan; Cubizolles, Myriam; Roupioz, Yoann; Buhot, Arnaud

doi:10.1016/j.jpba.2020.113777

Cited by 26 publications

(18 citation statements)

References 132 publications

(546 reference statements)

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“…35 Microfluidic patterns are directly machined from a cyclic olefin copolymer (COC) sheet (TOPAS, US) using DATRON M7HP equipment. The stretchable membrane is positioned between the fluidic card (1) and the pneumatic card (2). In this new microfluidic cartridge, both fluidic and pneumatic layers contain hemispherical chambers to increase the volumes of interest compared to our previous study.…”

Section: Chip Fabricationmentioning

confidence: 99%

“…For instance, in clinical diagnostics, the detection of cardiac biomarkers such as troponin 1 is of huge interest. 2 A portable device could improve chest pain patients' flow management in the emergency department. 3 Food safety is another broad field of application 1,4,5 where on site testing could provide fast results to isolate immediately a contaminated batch and prevent foodborne illnesses.…”

Section: Introductionmentioning

confidence: 99%

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A versatile and automated microfluidic platform for a quantitative magnetic bead based protocol: application to gluten detection

et al. 2022

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Section: Chip Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A versatile and automated microfluidic platform for a quantitative magnetic bead based protocol: application to gluten detection

et al. 2022

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“…Mortality profiles and trends are often presented to healthcare personnel as the basis for critical decisions regarding the public's welfare, now and in the future [8]. Since mortality is considered one constant demographic process, preventing its occurrence has been a motivation for the rapid cardiac health advancements available today [9]. Unfortunately, access to these developments is unequal among different population sectors, causing disparities in cardiac health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Heart disease mortality in the Philippines from 1960 to 2019: a big data analysis

Cabanlit

Morilla²,

Luga³

et al. 2023

IJPHS

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Heart diseases remain one of the major health concerns worldwide, inflicting a tremendous financial burden, especially in low to middle-income countries like the Philippines. An exhaustive time-trend analysis, including recent data, is essential to measure the nation's progress in cardiac health, capturing the effect of national-scale changes over time. Thus, using stored data from the Philippine health statistics, this study analyzed trends and profiles of heart disease mortality in the Philippines from 1960 to 2019 and discussed relevant national policies for greater recognition and awareness. Ischaemic heart disease constituted the most significant proportion of mortality among all types. Steadily increasing trends by cause, gender, age group were observed, and with males and the elderly population having higher rates. Regional differences also existed, having the highest rates in Luzon, the Visayas, and Mindanao respectively. Like global patterns, heart disease remained one of the country's leading causes of mortality over decades. Differences between genderes, age groups, and regions are attributed to complex and interrelated factors making males, the elderly, and highly urbanized areas most vulnerable among the population.

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“…CVD is a major public health concern and imposes a huge economic burden on people and governments. Cardiac troponin (cTn-I) is the most promising biomarker for CVD, and cTn-I biosensors are employed for the clinical diagnosis of CVD [ 3 ]. As the ranges of cTn-I levels in serum are in the pg/mL level, functional nanomaterials, which enhance the sensitivity and detection ranges of cTn-I biosensors, are needed to increase their performance [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Ruthenium and Nickel Molybdate-Decorated 2D Porous Graphitic Carbon Nitrides for Highly Sensitive Cardiac Troponin Biosensor

et al. 2022

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Two-dimensional (2D) layered materials functionalized with monometallic or bimetallic dopants are excellent materials to fabricate clinically useful biosensors. Herein, we report the synthesis of ruthenium nanoparticles (RuNPs) and nickel molybdate nanorods (NiMoO4 NRs) functionalized porous graphitic carbon nitrides (PCN) for the fabrication of sensitive and selective biosensors for cardiac troponin I (cTn-I). A wet chemical synthesis route was designed to synthesize PCN-RuNPs and PCN-NiMoO4 NRs. Morphological, elemental, spectroscopic, and electrochemical investigations confirmed the successful formation of these materials. PCN-RuNPs and PCN-NiMoO4 NRs interfaces showed significantly enhanced electrochemically active surface areas, abundant sites for immobilizing bioreceptors, porosity, and excellent aptamer capturing capacity. Both PCN-RuNPs and PCN-NiMoO4 NRs materials were used to develop cTn-I sensitive biosensors, which showed a working range of 0.1–10,000 ng/mL and LODs of 70.0 pg/mL and 50.0 pg/mL, respectively. In addition, the biosensors were highly selective and practically applicable. The functionalized 2D PCN materials are thus potential candidates to develop biosensors for detecting acute myocardial infractions.

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Recent advances in cardiac biomarkers detection: From commercial devices to emerging technologies

Cited by 26 publications

References 132 publications

A versatile and automated microfluidic platform for a quantitative magnetic bead based protocol: application to gluten detection

A versatile and automated microfluidic platform for a quantitative magnetic bead based protocol: application to gluten detection

Heart disease mortality in the Philippines from 1960 to 2019: a big data analysis

Ruthenium and Nickel Molybdate-Decorated 2D Porous Graphitic Carbon Nitrides for Highly Sensitive Cardiac Troponin Biosensor

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