Recent advances in carboxymethyl chitosan-based materials for biomedical applications

Geng, Yaoxiang; Xue, Hang; Zhang, Zhenhe; Knoedler, Samuel; Zhou, Wu; Mi, Bobin; Liu, Guohui

doi:10.1016/j.carbpol.2023.120555

Cited by 89 publications

(50 citation statements)

References 186 publications

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“…[ 10 ] It is well known that most bacterial surfaces have a large number of negative charges, [ 11 ] and we hypothesize that CMCS based wound dressings could generate electrostatic interactions with bacterial cell membranes through protonated amino groups, enhancing the ability to capture bacteria. [ 12 ] The antibacterial efficiency is improved by the effective confinement of bacteria in the damage range of reactive oxygen species (ROS). At the same time, the dead bacteria in the infected area are collected, reducing the adverse inflammatory response caused by the dead bacteria.…”

Section: Introductionmentioning

confidence: 99%

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Yang

Pan

et al. 2023

Adv Funct Materials

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Wound with drug-resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self-adapt to the need of different stage of wound healing remains challenging. Herein, self-adaptive wound dressings with multiple stimuli-responsiveness and antibacterial activity are developed. Specifically, MoS 2 carrying a reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L-arginine (MSPA) is designed and incorporated into carboxymethyl chitosan/poly(Nisopropylacrylamide) based cryogels (CMCS/PNIPAM) with multiple responsiveness (pH, near infrared (NIR), and temperature) to form self-adaptive antibacterial cryogels that adapt to the therapeutic needs of different stages in infected wound healing. In response to the slightly acidic environment of bacterial infection, the cryogels assist the bacterial capture capacity through acid-triggered protonation behavior, and effectively enhance the photodynamic antibacterial efficiency. Controllable on-demand delivery of ROS, NO, and remote management of infected biofluid are achieved with NIR light as a trigger switch. The multiple stimuli-responsive nanozyme-based cryogels efficiently eliminate MRSA bacterial biofilm through NO assisted photodynamicand photothermal therapy (PDT&PTT). The multiple enzyme-like activities of the cryogels effectively relieved oxidative damage. Notably, these cryogels effectively reduce wound infection, alleviated oxidative stress, and accelerate collagen deposition and angiogenesis in infected wounds, indicating that multiple stimuli-responsive self-adaptive wound dressings provide new ideas for infected wound treatment.

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Section: Introductionmentioning

confidence: 99%

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Yang

Pan

et al. 2023

Adv Funct Materials

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“…This phenomenon is attributed to the binding of the positively charged CPPO@CMC-PC-N to the negatively charged bacterial cell membrane in the acidic microenvironment of bacteria, which breaks the charge balance of the membrane and leads to the membrane rupture . Meanwhile, CMC itself also has a certain sterilization effect . In contrast, CPPO@CMC-PC-N showed more significant bactericidal efficacy toward E.…”

Section: Resultsmentioning

confidence: 99%

“…49 Meanwhile, CMC itself also has a certain sterilization effect. 50 In contrast, CPPO@CMC-PC-N showed more significant bactericidal efficacy toward E. coli (100%) and S. aureus (95.9%) after white light irradiation (100 mW cm −2 ) for 10 min (Figures 5a,b and S16), which was superior to commercial antibiotics. 51 At the same time, the bactericidal effect of CPPO@CMC-PC-N was explored when only PTT or PDT was performed according to the methods previously reported with a slight modification.…”

Section: And S15mentioning

confidence: 91%

pH-Responsive and Chemiluminescent Carboxyethyl Chitosan Nanocarriers for Intelligent Targeted Phototherapy Sterilization

Zhao

Yin

et al. 2023

ACS Appl. Nano Mater.

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The development of nanotechnology provides hope for precision sterilization, but traditional physical encapsulation of drugs and non-targeted treatments is prone to drug leakage and non-specific damage. Besides, traditional fluorescence imaging is subject to autofluorescence interference and non-specific damage caused by continuous excitation. Herein, we report a pH-/H 2 O 2activated and self-luminous nanosphere for intelligent bacteriatargeting and self-reported imaging-guided precision phototherapy sterilization. pH-responsive porphyrin derivative-grafted carboxymethyl chitosan (CMC-PC-N) was designed and synthesized as bacterial microenvironment-responsive nanocarriers and phototherapeutic agents. Peroxyoxalate (CPPO), a H 2 O 2 -responsive chemiluminescence substrate, was further employed as a built-in initiator for self-reported imaging and self-assembled with CMC-PC-N to form the nanosphere by nanoprecipitation (CPPO@ CMC-PC-N). Hydrophilicity of the nanosphere increases in the bacterial acidic microenvironment due to the protonation of N atoms in CPPO@CMC-PC-N, resulting in the dissociation of nanospheres and the rapid release of CPPO. As a result, the formed positively charged CMC-PC-N targets bacteria by electrostatic adsorption. Meanwhile, the reaction of the released CPPO with endogenous H 2 O 2 activates the fluorescence of the porphyrin to achieve self-report imaging. Also, precision phototherapy sterilization is further activated by external irradiation under imaging guidance. The microenvironment-triggered disassembly, rapid CPPO release, and self-luminous properties integrated with good biocompatibility ensure CPPO@CMC-PC-N intelligent bacteriatargeting, self-report imaging with non-background interference, and efficient phototherapy sterilization with negligible side effects.

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“…In most cases, the solubility of most hydrophobic polymers was improved by modification of the hydrophilic groups, further affording a good dispersion of hydrophilic CMs in the process of constructing CM-polymer hybrid materials. 129,145 In a latest research, Kal was introduced into carboxymethyl CS (CMCS)/ SA matrix to form a new type of composite hemostatic sponge (Fig. 7a), and this reaction involved ionic crosslinking, polyelectrolyte and freeze-drying techniques.…”

Section: Sponge Hemostatic Compositesmentioning

confidence: 99%

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Yang,

Wang,

Yang

et al. 2023

Biomater. Sci.

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Recent advances in carboxymethyl chitosan-based materials for biomedical applications

Cited by 89 publications

References 186 publications

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

pH-Responsive and Chemiluminescent Carboxyethyl Chitosan Nanocarriers for Intelligent Targeted Phototherapy Sterilization

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

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