Recent advances in biotransformation, extraction and green production of D-mannose

Abstract

D-mannose is a natural and biologically active monosaccharide. It is the C-2 epimer of glucose and a component of a variety of polysaccharides in plants. In addition, D-mannose also naturally exists in some cells of the human body and participates in the immune regulation of cells as a prebiotic. Its good physiological benefits to human health and wide application in the food and pharmaceutical industries have attracted widespread attention. Therefore, in-depth research on preparation methods of D-mannose has been widely developed. This article summarizes the main production methods of D-mannose in recent years, especially the in-depth excavation from biomass raw materials such as coffee grounds, konjac flour, acai berry, etc., to provide new ideas for the green manufacture of D-mannose.

Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota

“…The O -glycan profile was similar for INU (composed of β-1,2-linked fructose) and KGM (composed of glucomannan linked by β-1,4 glycosidic bonds), and was characterized by fewer terminally mono-fucosylated and sialylated O -glycans. This similarity might be explained by the degradation of free mannose by intestinal microorganisms ( Bifidobacterium and Lactobacillus ) 45 , as well as its isomerization to fructose via phosphomannose isomerase. The impact of structurally diverse dietary polysaccharides on intestinal bacteria or colonization with specific intestinal microorganisms on the O -glycans of intestinal mucins has been reported previously 18 , 23 .…”

Nanocoating-konjac application as postharvest handling to extend the shelf life of Siamese oranges

“…Konjac tubers contain glucomannan or a source of water-soluble fiber which is quite high, namely 79.91% (Xiao et al, 2022). Glucomannan from konjac is biodegradable, has antioxidant power, low toxicity, is cheap, and is easy to apply (Devaraj et al, 2019;Wang et al, 2022). The function of glucomannan is as an emulsifier or emulsifier which is often applied in the food industry because glucomannan can form a gel that has a fairly high viscosity when it is in a liquid (Suriati et al, 2020a).…”

Molybdenum sulfide-2D nanosheets offering multiple metallic sites enable different sugar epimerization reactions to rare sugars in water

“…Mannose is equally important in the pharmaceutical sector, as it is used to prepare immunostimulants, vitamins, anti-tumor-related drugs, and many others. 9 Therefore, efforts are also made to recover mannose rather than fructose using glucose, which comprises lignocellulose as cellulose (up to 35% by wt). 16 For its production, molybdenum (Mo) based catalysts, including molybdenum acid (homogeneous) and heterogeneous Mo-based polyoxometalates, immobilized molybdate on ion-exchange resin, heptamolybdate exchanged on SBA-15-type mesoporous silica and Na + ion-exchanged Sn-β, have shown promising results when using glucose.…”

“…Additionally, the traditional bioprocess encounters several challenges, including enzyme recovery and reuse, fast enzyme deactivation, prolonged reaction, purity substrate requirement, product downstreaming, and more. 8,9 Meanwhile, dedicated research is underway to develop a viable and cost-effective chemocatalytic method for the rapid production of these sugars. [10][11][12] For example, the chemical preparation of fructose via glucose isomerization is widely investigated using homogeneous and heterogeneous catalysis methods due to its importance in pharma, food and beverage products, 13 and energy chemical preparations.…”