Recent advances in biopolymer based electrospun nanomaterials for drug delivery systems

Abstract

Drug delivery systems, including liposomes, gels, prodrugs, and so forth, are used to enhance the tissue benefit of a pharmaceutical drug or conventional substance at a specific diseased site with little toxicological impact. Nanotechnology can be a rapidly developing multidisciplinary science that enables the production of polymers at the manometer scale for different medical applications. The use of biopolymers in drug delivery systems provides compatibility, biodegradability and low immunogenicity biologically. Large‐scale and smaller‐than‐expected medication particles can be delivered using biopolymers such as silk fibroins, collagen, gelatine, and others that are easily formed into suspensions. These drug carrier systems are functional at improving drug delivery and can be used in intranasal, transdermal, dental, and ocular delivery systems. This study discusses the latest developments in drug delivery methods based on nanomaterials, mainly using biopolymers like proteins and polysaccharides.

Electrospun Fenoprofen/Polycaprolactone @ Tranexamic Acid/Hydroxyapatite Nanofibers as Orthopedic Hemostasis Dressings

“…Electrospinning is a flexible top-down technique with a broad spectrum of regulatable parameters [98][99][100][101][102]. Based on the concept disclosed here, many new possibilities for developing novel hemostatic nanomaterials and other fantastic applications of electrospun architectures [103][104][105][106][107] can be anticipated.…”

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

“…An example of a natural polymer widely studied for designing advanced drug delivery systems, both as a carrier and as an excipient, is nanocellulose, which has demonstrated great potential due to its high surface area-to-volume ratio and high polymerization, which determine the high loading and binding of active pharmaceutical ingredients, along with the control of the drug release [21]. Biopolymers derived from polysaccharides (such as chitosan and hyaluronic acid) and proteins (such as silk fibroin and collagen) are becoming more popular than synthetic polymers [3,19,22,23] and have been investigated for higher therapeutic outcomes and for potential scale-up to clinical level [3,19].…”