Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Patel, Dinesh K.; Jung, Eunseo; Priya, Sahariya; Won, So-Yeon; Han, Sung Soo

doi:10.1016/j.carbpol.2023.121408

Cited by 35 publications

(12 citation statements)

References 243 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, their limited mechanical strength restricts their range of applications. This drawback can be overcome in synthetic polymer-based hydrogels by controlling the structure or functional groups of the polymer chains[ 94 ]. Biocompatible hydrogels are extensively used in tissue engineering applications such as wound healing, bone regeneration, drug delivery, and cell delivery[ 95 ].…”

Section: Scaffold Materialsmentioning

confidence: 99%

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Xiang,

Kang,

et al. 2024

World J Stem Cells

View full text Add to dashboard Cite

Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibiting significant potential for enhancing wound healing rates, improving wound quality, and promoting skin regeneration. However, the use of stem cells in skin regeneration presents several challenges. Recently, stem cells and biomaterials have been identified as crucial components of the wound-healing process. Combination therapy involving the development of biocompatible scaffolds, accompanying cells, multiple biological factors, and structures resembling the natural extracellular matrix (ECM) has gained considerable attention. Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells, providing them with an environment conducive to growth, similar to that of the ECM. These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing. This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing, emphasizing their capacity to facilitate stem cell adhesion, proliferation, differentiation, and paracrine functions. Additionally, we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

show abstract

Section: Scaffold Materialsmentioning

confidence: 99%

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Xiang,

Kang,

et al. 2024

World J Stem Cells

View full text Add to dashboard Cite

show abstract

“…Hydrogels, characterized by their unique three-dimensional networks of hydrophilic polymers, have emerged as a cornerstone in the advancement of biomaterial science, revolutionizing applications across a broad spectrum of biomedical fields [1][2][3][4][5][6][7][8]. These networks, capable of absorbing and retaining substantial volumes of water, are distinguished by their remarkable ability to swell without dissolution, maintaining structural integrity through chemical or physical cross-linking mechanisms [9,10].…”

Section: Introductionmentioning

confidence: 99%

Advances in Hydrogel-Based Drug Delivery Systems

Liu,

Chen

2024

Gels

View full text Add to dashboard Cite

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.

show abstract

“…Hydrogels exhibit promising potential for utilization in flexible wearable sensors [ 1 ], tissue engineering [ 2 ], biomedicine [ 3 ], and intelligent robots [ 4 ], as a result of their high water content [ 5 ], good viscoelasticity [ 6 ], well transparency [ 7 ], and high biocompatibility [ 8 ]. Hydrogel-based electronic devices have garnered growing interest as a result of their remarkable flexibility and extensibility [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Dual-Network Polymer Hydrogels with Anti-Freezing, Highly Conductive, and Self-Healing Properties

Jin,

Zhao,

Jiang

et al. 2024

Materials

View full text Add to dashboard Cite

We report the synthesis of poly(acrylamide-co-acrylic acid)/sodium carboxy methyl cellulose (PAMAA/CMC-Na) hydrogels, and subsequent fabrication of dual-network polymer hydrogels (PAMAA/CMC-Na/Fe) using as-prepared via the salt solution (FeCl3) immersion method. The created dual-network polymer hydrogels exhibit anti-swelling properties, frost resistance, high conductivity, and good mechanical performance. The hydrogel swells sightly when immersed in solution (pH = 2~11). With the increase in nAA:nAM, the modulus of elasticity experiences a rise from 1.1 to 1.6 MPa, while the toughness undergoes an increase from 0.18 to 0.24 MJ/m3. Furthermore, the presence of a high concentration of CMC-Na also contributes to the enhancement of mechanical strength in the resulting hydrogels, ascribing to enhanced physical network of the hydrogels. The minimum freezing point reaches −21.8 °C when the CMC-Na concentration is 2.5%, owing to the dissipated hydrogen bonds by the coordination of Fe3+ with carboxyl (-COO−) in CMC-Na and PAMAA. It is found that the conductivity of the PAMAA/CMC-Na/Fe hydrogels gradually decreased from 2.62 to 0.6 S/m as the concentration of CMC-Na rises. The obtained results indicates that the dual-network hydrogels with high mechanical properties, anti-swelling properties, frost resistance, and electrical conductivity can be a competitive substance used in the production of bendable sensors and biosensors.

show abstract

Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Cited by 35 publications

References 243 publications

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Advances in Hydrogel-Based Drug Delivery Systems

Facile Synthesis of Dual-Network Polymer Hydrogels with Anti-Freezing, Highly Conductive, and Self-Healing Properties

Contact Info

Product

Resources

About