Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

Liao, Jun; Fan, Lisha; Li, Yang; Xü, Qiang; Xiong, Liangshan; Zhang, Shanshan; Liu, Jia‐Xian; Xiao, Zhi‐Cheng; Zhang, Chuan; Yang, Jian; Chen, Zhe‐Sheng; Xiao, Kai; Wang, Tingfang; Lu, Ying

doi:10.1016/j.jconrel.2023.05.009

Cited by 19 publications

(5 citation statements)

References 176 publications

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“…As the most selective physiological barrier in the human body ( Liao et al, 2023 ), the BBB protects the CNS from potentially harmful substances, although this also presents considerable challenges for the treatment of CNS disease ( Nilles et al, 2022 ). Many drugs cannot penetrate the BBB, resulting in an insufficient effective concentration of drugs ( Yang et al, 2019 ).…”

Section: Protective Effects Of Salvianic Acid a Against Cerebral I/r ...mentioning

confidence: 99%

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Yang,

Chen,

et al. 2023

Front. Pharmacol.

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Ischemia-reperfusion (I/R) injury refers to a new injury caused by reperfusion after the restoration of ischemic tissue or organ blood supply. Salvianic acid A (danshensu) is a primary active ingredient extracted from Salvia miltiorrhiza. It has a protective function against I/R injury in the cardiovascular system, brain, liver, kidney, gastrointestinal tract, and other organs. This article reviews evidence of the protective effects of Salvianic acid A and its potential mechanisms of action in organ I/R injury protection. The aim of this review is to investigate the role of Salvianic acid A in the treatment of I/R injury, providing a reference resource that could facilitate subsequent studies.

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Section: Protective Effects Of Salvianic Acid a Against Cerebral I/r ...mentioning

confidence: 99%

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Yang,

Chen,

et al. 2023

Front. Pharmacol.

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“…The application of CMNVs in the treatment of IS has recently been reviewed. Li et al and Liao et al provided overviews of the applications of CMNVs in various brain diseases, including gliomas, IS, Parkinson’s disease, and Alzheimer’s disease [ 29 ]. Liu et al specifically focused on the progress of CMNVs in IS treatment.…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

Hao,

Sha,

et al. 2023

Pharmaceutics

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Ischemic stroke (IS) is a prevalent form of stroke and a leading cause of mortality and disability. Recently, cell membrane-derived nanovehicles (CMNVs) derived from erythrocytes, thrombocytes, neutrophils, macrophages, neural stem cells, and cancer cells have shown great promise as drug delivery systems for IS treatment. By precisely controlling drug release rates and targeting specific sites in the brain, CMNVs enable the reduction in drug dosage and minimization of side effects, thus significantly enhancing therapeutic strategies and approaches for IS. While there are some reviews regarding the applications of CMNVs in the treatment of IS, there has been limited attention given to important aspects such as carrier construction, structural design, and functional modification. Therefore, this review aims to address these key issues in CMNVs preparation, structural composition, modification, and other relevant aspects, with a specific focus on targeted therapy for IS. Finally, the challenges and prospects in this field are discussed.

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“… 10 The need for new treatments for neurodegenerative diseases and the limitations imposed by the BBB are driving the adoption of nanotechnology. 11 Exosomes (Exos) are extracellular nanovesicles that participate in various physiological processes and exert pathological activities, including intracellular signalling and intercellular transport of protein and RNA. 12 Emerging clinicopathological and experimental studies have suggested the crucial role of Exos in intercellular communication and in the transportation of materials in the CNS and their excellent biocompatibility for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

Zhao,

Ge,

Lei

et al. 2023

DDDT

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Introduction Neuroinflammation is one of the major pathogeneses in Alzheimer’s disease (AD) and mainly involves abnormal inflammatory activation of microglia by multiple pathological stimuli. The treatment of AD remains a major challenge due to the multifactorial characterization of AD and the inefficient ability of therapeutic drugs to permeate through the blood‒brain barrier (BBB). Accordingly, drug combination treatment and drug carrier delivery have become important therapeutic tools for the treatment of multifactorial diseases, especially AD. Methods Inflammatory cytokine levels in microglia, including NO, TNF-α, IL-1β, IL-4, and IL-10, were detected. The Morris water maze and object location task were used to investigate the learning and memory functions of APP/PS1 mice in different treatment groups. The number of neurons and plasticity of synapses were evaluated by immunofluorescence double labelling. Additionally, the ratio of β-amyloid plaques and the number of activated microglia were evaluated by immunofluorescence staining. The concentrations of β-amyloid plaques and inflammatory factors in the hippocampus were determined by ELISA. Microglia-derived exosomes (Exos) were extracted and purified by size exclusion chromatography. The distribution of exosomes and drugs was investigated in vitro and in vivo. Results Compared to single drug interventions, the combination of Ber and Pal (Ber/Pal) modulated microglial inflammatory cytokine levels. Ber/Pal promoted the recovery of learning and memory impairment in APP/PS1 mice. Immunofluorescence staining indicated that Ber/Pal restored neurons, inhibited Aβ plaque formation and microglial activation, and regulated the secretion of inflammatory factors. Exos promoted the accumulation of drugs in cells and tissues and improved the targeting of drugs across the BBB. Conclusion Ber/Pal could offer a synergistic and more comprehensive therapeutic effect in AD. Additionally, the microglia-derived Exos-Ber/Pal delivery system promoted the targeting and permeation of drugs into the brain, suggesting a creative strategy for targeting AD therapy by regulating neuroinflammation in microglial cells.

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Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

Cited by 19 publications

References 176 publications

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application

An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

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