Recent advances in biological production of 1,3-propanediol: new routes and engineering strategies

Abstract

1,3-Propanediol (1,3-PDO) is an important chemical which has been widely used in cosmetic, pharmaceutical, and especially polymer industries. Production of 1,3-PDO from renewable feedstocks by green processes is attracting broad...

Block Poly(carbonate‐ester) Ionomers as High‐Performance and Recyclable Thermoplastic Elastomers

“… [37b] The concomitantly released 1,3‐propanediol is widely used in the cosmetics, pharmaceutical and polymer industries and is the precursor to reforming TMC monomer with CO 2 . [23] Under these depolymerization conditions, 1 H NMR spectroscopy of the crude reaction mixture suggests polyester conversion to the ring‐opened epoxide and phthalate ester of the diol (Figure S30–31).…”

“…A challenge however, is to achieve fully reversible SIC to ensure excellent elastic recovery. [22] PTMC is best synthesised by the ROP of TMC, which in turn can be bio‐sourced by coupling 1,3‐propanediol (a fermentation product of carbohydrates) [23] with carbon dioxide. [24] Here, in one‐pot, TMC ROP is switched to PA/vinyl‐cyclohexene oxide (vCHO) or limonene oxide (LO) ROCOP to deliver ABA‐block polymer TPEs.…”

Characterization and engineering of branched short-chain dicarboxylate metabolism in Pseudomonas reveals resistance to fungal 2-hydroxyparaconate

“…Interestingly, 2,4-DHB was identified as an inhibitor of the eukaryotic malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate, which is a relevant reaction for a wide range of metabolic pathways ( Rognstad and Katz, 1979 ; Schimerlik and Cleland, 1977 ). So far, no native bacterial pathway is known for the production of 2,4-DHB, although a synthetic pathway was recently described from malate via malyl-4-phosphate and malate-4-semialdehyde ( Zhu et al, 2022 ). Given the circumstances, it is more likely that 2,4-DHB is produced from ITT ( Fig.…”

Block Poly(carbonate‐ester) Ionomers as High‐Performance and Recyclable Thermoplastic Elastomers

“…Ethylene carbonate (EC) isolated here in 80 % yield is a widely employed liquid electrolyte and the TMC derivatives are useful ROP monomers [37b] . The concomitantly released 1,3‐propanediol is widely used in the cosmetics, pharmaceutical and polymer industries and is the precursor to reforming TMC monomer with CO 2 [23] . Under these depolymerization conditions, 1 H NMR spectroscopy of the crude reaction mixture suggests polyester conversion to the ring‐opened epoxide and phthalate ester of the diol (Figure S30–31).…”

“…A challenge however, is to achieve fully reversible SIC to ensure excellent elastic recovery. [22] PTMC is best synthesised by the ROP of TMC, which in turn can be bio-sourced by coupling 1,3-propanediol (a fermentation product of carbohydrates) [23] with carbon dioxide. [24] Here, in one-pot, TMC ROP is switched to PA/ vinyl-cyclohexene oxide (vCHO) or limonene oxide (LO) ROCOP to deliver ABA-block polymer TPEs.…”