Recent advances in biofluid detection with micro/nanostructured bioelectronic devices

Li, Hu; Gu, Shaochun; Zhang, Qianmin; Kuang, Tairong; Chen, Feng; Yu, Xinge; Chang, Lingqian

doi:10.1039/d0nr07478k

Cited by 17 publications

(9 citation statements)

References 120 publications

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“…In addition, wound fluid collection and in situ sampling can be greatly improved by newly developed fabrication techniques such as microfluidics patterns. [116,[137][138][139][140][141]…”

Section: (12 Of 26)mentioning

confidence: 99%

Wearable Bioelectronics for Chronic Wound Management

Wang

Sani

Gao

2021

Adv Funct Materials

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Chronic wounds are a major healthcare issue and can adversely affect the lives of millions of patients around the world. The current wound management strategies have limited clinical efficacy due to labor-intensive lab analysis requirements, need for clinicians' experiences, long-term and frequent interventions, limiting therapeutic efficiency and applicability. The growing field of flexible bioelectronics enables a great potential for personalized wound care owing to its advantages such as wearability, low-cost, and rapid and simple application. Herein, recent advances in the development of wearable bioelectronics for monitoring and management of chronic wounds are comprehensively reviewed. First, the design principles and the key features of bioelectronics that can adapt to the unique wound milieu features are introduced. Next, the current state of wound biosensors and on-demand therapeutic systems are summarized and highlighted. Furthermore, the design criteria of the integrated closed loop devices are discussed. Finally, the future perspectives and challenges in wearable bioelectronics for wound care are discussed.

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“…In addition, wound fluid collection and in situ sampling can be greatly improved by newly developed fabrication techniques such as microfluidics patterns. [116,[137][138][139][140][141]…”

Section: (12 Of 26)mentioning

confidence: 99%

Wearable Bioelectronics for Chronic Wound Management

Wang

Sani

Gao

2021

Adv Funct Materials

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“…The traditional fingerstick blood glucose test requires carefully planned performance to catch the peaks and troughs of blood glucose levels, bringing inconvenience and pain to patients’ lives. For diabetic patients, daily health management relies heavily on invasive blood glucose testing multiple times per day, which makes a user-friendly system for painless, automatic, and continuous blood glucose measurement highly desirable 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Highly integrated watch for noninvasive continual glucose monitoring

Chang

Zhang

et al. 2022

Microsyst Nanoeng

Self Cite

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This article reports a highly integrated watch for noninvasive continual blood glucose monitoring. The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid (ISF) transdermally at the wrist. This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients’ lives, making continual blood glucose monitoring practical and easy. All electronic modules, including a rechargeable power source and other modules for signal processing and wireless transmission, are integrated onto a watch face-sized printed circuit board (PCB), enabling comfortable wearing of this continual glucose monitor. Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface. With 23 volunteers, the watch demonstrated 84.34% clinical accuracy in the Clarke error grid analysis (zones A + B). In the near future, commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

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“…Currently, on-skin electronics have progressed swiftly from onefold function to detecting sophisticated variables synchronously. Potential strategies, including structured resistive, impedance and/or capacitive ionotronics, and bioinspired structures, have been demonstrated to detect pressure, temperature, proximity, slip/friction force, vibration, and/or biofluid component analysis , simultaneously. Recently, with the imperious demands of dexterous perception, synergistically monitoring the proximity-contact events has been attracting broad research interest in tactile sensing.…”

Section: Introductionmentioning

confidence: 99%

Optical Microfibers for Sensing Proximity and Contact in Human–Machine Interfaces

Liu

Song

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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The monitoring of proximity-contact events is essential for human–machine interactions, intelligent robots, and healthcare monitoring. We report a dual-modal sensor made with two functionalized optical microfibers (MFs), which is inspired by the somatosensory system of human skin. The integrated sensor with a hierarchical structure gradationally detects finger approaching and touching by measuring the relative humidity (RH) and force-triggered light intensity variations. Specifically, the RH sensory part shows enhanced evanescent absorption, achieving a sensitive RH measurement with a fast response (110 ms), a high resolution (0.11%RH), and a wide working range (10–100%RH). Enabled by the transition from guided modes into radiation modes of the waveguiding MF, the force sensory part exhibits a high sensitivity (6.2%/kPa) and a fast response (up to 1.5 kHz). By using a real-time data processing unit, the proximity-contact sensor (PCS) achieves continuous detection of the full-contact events, including finger approaching, contacting, pressing, releasing, and leaving. As a proof of concept, the electromagnetic-interference-free PCS enables a smart switch system to recognize the proximity and contact of bare/gloved fingers. Moreover, skin humidity detection and respiration monitoring are realized. These initial results pave the way toward a category of optical collaborative devices ranging from human–machine interfaces to multifunctional on-skin healthcare sensors.

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Recent advances in biofluid detection with micro/nanostructured bioelectronic devices

Abstract: Micro/nanostructured bioelectronic devices for various biofluid detection applications are systematically summarized and discussed with new insights for future health monitoring.

Cited by 17 publications

References 120 publications

Wearable Bioelectronics for Chronic Wound Management

Wearable Bioelectronics for Chronic Wound Management

Highly integrated watch for noninvasive continual glucose monitoring

Optical Microfibers for Sensing Proximity and Contact in Human–Machine Interfaces

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