Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment

Lu, Jiaoying; Shen, Xinyuan; Li, Hongjun; Du, Juan

doi:10.1002/exp.20230142

Cited by 4 publications

(1 citation statement)

References 133 publications

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“…Many innovative techniques are being used to produce new forms in the oral cavity [ 13 , 14 ], one of which is electrospinning [ 15 ], a green manufacturing method with no negative impact on the environment and health [ 16 ]. The development of nanofibers has made it easier to create and use biomaterials as three-dimensional artificial scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Paczkowska-Walendowska,

Ignacyk,

Miklaszewski

et al. 2024

Materials

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Pomegranate peel extract is known for its potent antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic properties, leading to its use in treating oral infections. In the first stage of this work, for the first time, using the Design of Experiment (DoE) approach, pomegranate peel extract (70% methanol, temperature 70 °C, and three cycles per 90 min) was optimized and obtained, which showed optimal antioxidant and anti-inflammatory properties. The optimized extract showed antibacterial activity against oral pathogenic bacteria. The second part of this study focused on optimizing an electrospinning process for a combination of polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) nanofibers loaded with the optimized pomegranate peel extract. The characterization of the nanofibers was confirmed by using SEM pictures, XRPD diffractograms, and IR-ATR spectra. The composition of the nanofibers can control the release; in the case of PVP–based nanofibers, immediate release was achieved within 30 min, while in the case of PCL/PVP, controlled release was completed within 24 h. Analysis of the effect of different scaffold compositions of the obtained electrofibers showed that those based on PCL/PVP had better wound healing potential. The proposed strategy to produce electrospun nanofibers with pomegranate peel extract is the first and innovative approach to better use the synergy of biological action of active compounds present in extracts in a patient-friendly pharmaceutical form, beneficial for treating oral infections.

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Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Paczkowska-Walendowska,

Ignacyk,

Miklaszewski

et al. 2024

Materials

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Oral Administration Properties Evaluation of Three Milk‐Derived Extracellular Vesicles Based on Ultracentrifugation Extraction Methods

Xia,

Hu,

Chen

et al. 2024

Adv Healthcare Materials

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Milk‐derived extracellular vesicles (M‐EVs) are low‐cost, can be prepared in large quantities, and can cross the gastrointestinal barrier for oral administration. However, the composition of milk is complex, and M‐EVs obtained by different extraction methods may affect their oral delivery. Based on this, we propose a new method for extracting M‐EVs based on cryogenic freezing treatment (Cryo‐M‐EVs) and compare this method with the previously reported acetic acid treatment (Acid‐M‐EVs) method and the conventional ultracentrifugation method (Ulltr‐M‐EVs). The new method simplifies the pretreatment step and achieves 25‐fold and 2‐fold higher yields than Acid‐M‐EVs and Ulltr‐M‐EVs. And it was interesting to note that Cryo‐M‐EVs and Acid‐M‐EVs had higher cellular uptake efficiency, and Cryo‐M‐EVs presented the best transepithelial transport effect. After oral administration of the three M‐EVs extracted by three methods in mice, Cryo‐M‐EVs effectively successfully crossed the gastrointestinal barrier and achieved hepatic accumulation, whereas Acid‐M‐EVs and Ultr‐M‐EVs mostly resided in the intestine. The M‐EVs obtained by the three extraction methods showed a favorable safety profile at the cellular as well as animal level. Therefore, when M‐EVs obtained by different extraction methods are used for oral drug delivery, we can utilize their accumulation properties at different sites to better deal with different diseases.This article is protected by copyright. All rights reserved

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Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome

Huang,

Xu,

Sun

et al. 2025

Biomaterials

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Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment

Cited by 4 publications

References 133 publications

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Electrospun Nanofibers with Pomegranate Peel Extract as a New Concept for Treating Oral Infections

Oral Administration Properties Evaluation of Three Milk‐Derived Extracellular Vesicles Based on Ultracentrifugation Extraction Methods

Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome

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