Recent Advances in Asymmetric Wittig-Type Reactions.

Enzymatic synthesis of chiral P-stereogenic phosphonoacetates

“…IR spectra were obtained using a JASCO FT/IR-420 IR Fourier transform spectrometer. 1 H-NMR (400 MHz) and 13 C-NMR (75 MHz) spectra were recorded on JEOL JNM-AL400, Bruker AV400N, and JEOL JNM-AL300 spectrometers, respectively. Chemical shifts are given in δ values (parts per million) using tetramethylsilane (TMS) as an internal standard.…”

“…Chiral Horner-Wadsworth-Emmons (HWE) reagents are extremely useful for asymmetric olefination of prochiral aldehydes or ketones [1][2][3][4]. However, most of these chiral HWE reagents are restricted to the compounds with non-stereogenic phosphorus atom, which are more easily available than P-stereogenic HWE reagents.…”

Synthesis of novel phenylenevinylene linkers with electron-donating substituents by the Heck reaction

“…If a mixture of EE,EZ, and ZZ OPV isomers was used, then uniform MOF networks would not form, and the optoelectronic properties would be adversely affected [12]. Many advances have been reported for improving stereoselectivity in the synthesis of OPVs using common methodologies, such as the Wittig reaction [13][14][15]. The present work introduces an alternative route to OPVs based on the Heck reaction.…”

Convergent Synthesis of Polysubstituted Furans via Catalytic Phosphine Mediated Multicomponent Reactions

“…The troublesome purification of the by-products [5] makes them valueless on an industrial scale [6][7][8]. Also, most well-designed phosphines, especially chiral phosphine reagents [9][10][11][12][13][14][15], are very expensive and high cost hampers their applications in asymmetric Wittig reaction [16][17][18][19][20][21][22][23][24][25]. In this context, it is highly desired to develop a catalytic version of phosphine-mediated Wittig reaction by in-situ recycling by-product phosphine oxide under the aid of a reducing agent.…”