Recent advances in asymmetric synthesis with CO2

Nickel‐Catalyzed Asymmetric Reductive Carbo‐Carboxylation of Alkenes with CO2

“…Further systematical investigation of bases and solvents failed to give superior results than entry 12 (see the Supporting Information for details). Control experiments showed that Ni-catalyst, ligand and Zn were all indispensable in this reductive transformation (entries [13][14][15]. Furthermore,t he basic LiO t Bu and Lewis acidic MgCl 2 additive were also important for this transformation to achieve high yield (entries [16][17].…”

“…More significantly,wemight be able to synthesize high valueadded enantiomerically pure carboxylic acids through chiral ligands-induced asymmetric reductive alkene carbo-carboxylation reaction, which has not been disclosed yet. [14,15] Indoline-and oxindole-3-acetic acid derivatives bearing aC 3-quaternary stereocenter are not only widely found in bioactive molecules and natural products but also serve as key precursors to construct complex molecules (Figure 2). [16] Although some approaches, [17] such as Pd-catalyzed asymmetric carbonylation with CO as the carbonyl source, [17a,f,g] have been reported to obtain these core structures,itishighly desirable to seek more cost-efficient catalysts and userfriendly carbonyl source.I nspired by recent great progress on reductive cross couplings, [18][19][20][21] we hypothesized whether we could synthesize these structures via asymmetric reductive carbo-carboxylation of aryl (pseudo)halides-tethered acrylamides using inexpensive transition-metal catalyst and nontoxic CO 2 as carboxyl source.T or ealize this transformation, several challenges need to be resolved.…”

Utilization of CO2 Feedstock for Organic Synthesis by Visible‐Light Photoredox Catalysis

“…Dedicated mechanistic interrogation may resolve the pitfalls associated with existing methods to improve the outputs and design principles. Accessing diastereo‐ and enantioselectivity of CO 2 incorporation into organic substrates has rarely been explored and thus offers further opportunity for future developments [46] . Consequently, the development of asymmetric carboxylative processes with CO 2 as a carbon source under milder conditions will surely motivate the chemistry community to work more deeply on this blooming area of research.…”

“…Accessingd iastereo-and enantioselectivity of CO 2 incorporation into organic substrates has rarely been explored and thus offers furthero pportunity for future developments. [46] Consequently,t he development of asymmetric carboxylative processesw ith CO 2 as ac arbon source under milder conditions will surely motivate the chemistry community to work more deeply on this blooming area of research. We anticipatet hat the combined venture of renewable resources of CO 2 and light energy will further be evolved in the future owing to the demandf or globalsustainability.…”

Pyrene-based ammonium bromides combined with g-C3N4for the synergistically enhanced fixation reaction of CO2and epoxides

“…[2][3][4][5][6][7] Among these conversions, the generation of cyclic carbonates, a popular group of chemicals, is recognized as an effective route to convert inert CO 2 with epoxides. [8][9][10][11][12][13][14][15][16] In addition, cyclic carbonates are established as not only valuable materials with various industrial applications for polymer synthesis, aprotic polar solvents, fuel additives and electrolyte solvents in lithium-ion batteries but also crucial intermediates in the manufacturing of ne chemicals. 17,18 In fact, there are quite a few materials on the utilization of CO 2 xation, including homogeneous and heterogenous catalysts, for example, ionic liquids, 19,20 organocatalysts, [21][22][23] Salen, [24][25][26] porphyrins, 27 alkali salts, 28 covalent-organic frameworks (COFs), 29 metal-organic frameworks (MOFs) 30 and covalent organic polymers (COPs).…”