Recent Advances in Asymmetric C—C and C‐Heteroatom Bond Forming Reactions Using Polymer‐Bound Catalysts

Abstract

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Recent Applications of Polymer Supported Organometallic Catalysts in Organic Synthesis

“…Palladium is probably the most versatile of elements for application in organic synthesis, and it is therefore not surprising that the majority of reports concerning supported organometallic reagents for synthetic purposes deal with complexes involving this metal. For earlier reports on polymer supported palladium complexes, we refer the readers to a comprehensive review by Bräse [ 6 ]. Methods for carbon-carbon cross-coupling such as the Suzuki, Heck and Sonogashira reactions are the most common applications for polymer bound palladium complexes.…”

“…This review covers literature concerning the application of polymer bound organometallic reagents in organic synthesis from 2007 until May 2010; for earlier reports in this area we refer to comprehensive reviews covering the time up to 2007 [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Likewise, solid phase organometallic chemistry where the substrate, rather than the catalyst, is attached to the support is not included, but reviews summarizing this field are available [ 9 , 10 , 11 ].…”

Cheap and Long‐Life Reusable Polymer for Asymmetric Organozinc Catalysis Based on Camphor‐Derived Hydroxyamides

“…This possibility is very interesting for sustainable organozinc‐catalyzed processes, especially when they must be performed at the industrial multikilogram level. Supporting the chiral‐ligand moiety in a polymeric solid matrix (i.e., polystyrene (PS)) is usually the best option for designing reusable functional polymers that can be recovered by simple filtration . However, the development of a heterogeneous supported catalyst is not trivial, and in many cases, the catalytic activity can be negatively affected by the supporting matrix .…”

“…Supporting the chiral‐ligand moiety in a polymeric solid matrix (i.e., polystyrene (PS)) is usually the best option for designing reusable functional polymers that can be recovered by simple filtration . However, the development of a heterogeneous supported catalyst is not trivial, and in many cases, the catalytic activity can be negatively affected by the supporting matrix . Moreover, it is well known that the successive recovering–recycling–reusing cycles used to decrease the catalyst activity, which can be overridden by enhancing the chemical robustness of the active ligand in some cases …”