Recent advances in assembly strategies of new advanced materials-based analytical methods for the detection of cardiac biomarkers as a diagnosis tool

Mansouri, S.; Altalbawy, Farag M. A.; Kareem, A.K.; Alhachami, Firas Rahi; Ramírez‐Coronel, Andrés Alexis; Gatea, M. Abdulfadhil; Romero-Parra, Rosario Mireya; Mustafa, Yasser Fakri; Jawhar, Zanko Hassan

doi:10.1016/j.microc.2023.108827

Cited by 4 publications

(2 citation statements)

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“…Acute myocardial infarction (AMI) is a serious cardiovascular disease and a main cause of human death globally. − According to the existing methods, the detection of cardiac biomarkers is the most effective strategy for early AMI diagnosis. − Potential biomarkers with high feasibility are cardiac troponin I (cTnI), creatine kinase-MB isoenzymes (CK-MB), and heart-type fatty acid-binding protein (H-FABP), which are large molecular proteins in body fluids. − Despite cTnI being the “gold standard” for AMI diagnosis, its early-stage sensitivity is suboptimal. − Alternatively, H-FABP can be rapidly released into the blood when the myocardium is damaged, making it an ideal early-stage AMI marker with high sensitivity and specificity. ,,,− At present, various practicable methods are investigated to detect H-FABP, including lateral flow immunoassay, photoelectrochemical, fluorescence (FL) analysis, and electrochemical methods . However, these methods have some limitations, such as cumbersome procedures and a long operating time. − Consequently, there is a critical need for a convenient and accurate method to detect H-FABP in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Multimetal-Based Metal–Organic Framework System for the Sensitive Detection of Heart-Type Fatty Acid Binding Protein in Electrochemiluminescence Immunoassay

Li,

Zhao,

et al. 2024

Anal. Chem.

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In this work, an electrochemiluminescence (ECL) quenching system using multimetal−organic frameworks (MMOFs) was proposed for the sensitive and specific detection of heart-type fatty acid-binding protein (H-FABP), a marker of acute myocardial infarction (AMI). Bimetallic MOFs containing Ru and Mn as metal centers were synthesized via a one-step hydrothermal method, yielding RuMn MOFs as the ECL emitter. The RuMn MOFs not only possessed the strong ECL performance of Ru(bpy) 3 2+ but also maintained high porosity and original metal active sites characteristic of MOFs. Moreover, under the synergistic effect of MOFs and Ru(bpy) 3 2+ , RuMn MOFs have more efficient and stable ECL emission. The trimetal-based MOF (FePtRh MOF) was used as the ECL quencher because of the electron transfer between FePtRh MOFs and RuMn MOFs. In addition, active intramolecular electron transfer from Pt to Fe or Rh atoms also occurred in FePtRh MOFs, which could promote intermolecular electron transfer and improve electron transfer efficiency to enhance the quenching efficiency. The proposed ECL immunosensor demonstrated a wide dynamic range and a low detection limit of 0.01−100 ng mL −1 and 6.8 pg mL −1 , respectively, under optimal conditions. The ECL quenching system also presented good specificity, stability, and reproducibility. Therefore, an alternative method for H-FABP detection in clinical diagnosis was provided by this study, highlighting the potential of MMOFs in advancing ECL technology.

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Section: Introductionmentioning

confidence: 99%

Multimetal-Based Metal–Organic Framework System for the Sensitive Detection of Heart-Type Fatty Acid Binding Protein in Electrochemiluminescence Immunoassay

Li,

Zhao,

et al. 2024

Anal. Chem.

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“…As a result, it becomes vital to develop an accurate and reliable method and/or platform for the early diagnosis of AMI. Developing such a platform/method will profoundly impact the medical diagnosis of AMI and the timely prevention of AMI [3][4][5][6][7][8] . It is well known that at the onset of AMI or within a few hours of AMI, a tiny (approx.…”

Section: Introductionmentioning

confidence: 99%