Recent advances in assemblies of cyclodextrins and amphiphiles: construction and regulation

Liu, Kaerdun; Ma, Cheng; Wu, Tongyue; Yan, Yun; Yan, Yun; Huang, Jianbin

doi:10.1016/j.cocis.2019.11.007

Cited by 28 publications

(32 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As it can be noticed from Figure 1, the cavity size of the CDs is dependent on the number of glucose units in the cycle (Carneiro et al, 2019). The three major CDs presented in Figure 1, α-, β-, and γ-CDs, represent the smallest members of these cyclic oligosaccharides family, consisting of 6, 7, and 8 glucose units, respectively (Fenyvesi and Szente, 2016;Liu et al, 2019). All three CDs occur naturally via enzymatic degradation of starch and have similar properties (Leclercq, 2016a;Li et al, 2014).…”

Section: Chemical Structure and Propertiesmentioning

confidence: 92%

“…CDs are glucose oligomers consisting of at least 6 (α-1,4)-linked α-D-glucopyranose units, that have a truncated funnel-shaped cage structure, with a hydrophobic inner cavity and hydrophilic outer surface (Fenyvesi and Szente, 2016;Hammoud et al, 2019;Liu et al, 2019;Loftsson et al, 2005).…”

Section: Chemical Structure and Propertiesmentioning

confidence: 99%

“…In what concerns the polarity of encapsulated molecules, the lipophilicity of the cavity favorizes the complexation with lipophilic entities or lipophilic parts of amphiphilic molecules, with either linear or cross-linked structures (Liu et al, 2019;Radu et al, 2016). Due to the unique conformation of CDs, they can entrap one or more drug molecules within one, two, or even three cavities, but the host : guest ratio is usually 1 : 1 (Crini et al, 2018b;Qiu et al, 2017).…”

Section: Inclusion Complexesmentioning

confidence: 99%

See 2 more Smart Citations

Cyclodextrins – development and applications of these versatile oligosaccharides

2020

Biomater Tissue Eng Bull

View full text Add to dashboard Cite

. Cyclodextrins (CDs) are cyclic oligossacharides which have been known and studied for almost 130 years. This review aims to highlight the most important findings registered over this time, the physicochemical properties, preparation methods and uses of cyclodextrins, with special focus on their recently discovered applications. Due to their unique conformation, cyclodextrins are able to encapsulate a wide range of chemical entities, impacting on their solubility, bioavailability, stability, and shelf-life. Their complex formation properties together with the production from natural sources opens the door for cyclodextrins to be used in numerous and varied industries. However, the most important consumer of these versatile sugars is represented by the biomedical domain, where cyclodextrins find uses in drug formulations, delivery systems, medical textiles, implantable devices, tissue engineering, and many other connex applications. Moreover, intense research is still performed for this compounds, to develop and extend their therapeutic potential and serve as promising alternatives for treatment of severe diseases.

show abstract

Section: Chemical Structure and Propertiesmentioning

confidence: 92%

Section: Chemical Structure and Propertiesmentioning

confidence: 99%

Section: Inclusion Complexesmentioning

confidence: 99%

See 1 more Smart Citation

Cyclodextrins – development and applications of these versatile oligosaccharides

2020

Biomater Tissue Eng Bull

View full text Add to dashboard Cite

show abstract

“…As a carrier material, β‐cyclodextrin was widely used in food and drug inclusion (Lima et al., 2016; Thongnopkoon & Chittasupho, 2018), it has a lipophilic cavity, and its diameter is suitable for nonpolar guest molecules. Furthermore, it can change the physical and chemical properties of inclusion materials and improve the solubility and stability of substances (Ivanova et al., 2015; Liu et al., 2020; Patel et al., 2015). To protect the lipophilic components that are sensitive to oxygen and light or heat‐induced degradation, cyclodextrin has been recommended for use in processing (Xie et al., 2016; Zhang et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

“…On the basis of theoretical calculation and preliminary cyclodextrin studies, polymers and amphiphilic substances can be the third or fourth excipients to form cyclodextrin multiple‐component systems. Various cyclodextrin multiple‐component systems have been studied for further improving the solubilization performance and transport of substances (Liu et al., 2020; Zhao et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Preparation, optimization, characterization, and in vitro bioaccessibility of a lutein microparticle using spray drying with β‐cyclodextrin and stevioside

Dai

et al. 2020

J Food Process Preserv

View full text Add to dashboard Cite

In this study, the powder of a lutein microparticle was prepared by spray drying with amphiphilic stevioside and β‐cyclodextrin as coating materials was developed to improve the solubility and bioaccessibility of lutein. Response surface methodology was used to optimize the preparation process with the drug loading capacity as index, indicating the optimal spray drying conditions were obtained as follows: feed rate of 500 ml h−1, inlet air temperature of 180°C, lutein amount of 649.4 mg, stevioside amount of 596.4 mg, and β‐cyclodextrin of 2,591.1 mg. The highest lutein loading capacity obtained was 325.7 mg g−1, resulting in high in vitro bioaccessibility of lutein (increased by twofold), which attributed to the increased solubilization capacity. The optimized lutein microparticle powders appeared spherical agglomerated structure under SEM, DSC analysis showed that the partial structure of lutein interacted with stevioside and was encapsulated by β‐cyclodextrin, FT‐IR result showed that noncovalent interactions mainly occurred between lutein and the carriers. The results suggested that the above lutein microencapsules could exhibit good potential for the bioavailability of lutein. Practical applications Lutein has widely gained considerable popularity as a food additive. To improve the solubility and bioaccessibility of lutein, lutein microparticle was successfully encapsulated with stevioside and β‐cyclodextrin by spray drying. A method for optimizing encapsulation conditions of high loading lutein microparticle powder using Box–Behnken design was studied. The result of this study can be useful for process optimization and has a significant effect on developing higher bioaccessibility for the product of lutein.

show abstract

Comparative chemical examination of inclusion complexes formed with β-cyclodextrin derivatives and basic amino acids

Esmaeilpour

Shityakov

Tamaddon

et al. 2021

Carbohydrate Polymers

View full text Add to dashboard Cite

Recent advances in assemblies of cyclodextrins and amphiphiles: construction and regulation

Cited by 28 publications

References 55 publications

Cyclodextrins – development and applications of these versatile oligosaccharides

Cyclodextrins – development and applications of these versatile oligosaccharides

Preparation, optimization, characterization, and in vitro bioaccessibility of a lutein microparticle using spray drying with β‐cyclodextrin and stevioside

Comparative chemical examination of inclusion complexes formed with β-cyclodextrin derivatives and basic amino acids

Contact Info

Product

Resources

About