2023
DOI: 10.3389/fimmu.2023.1080238
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Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine

Abstract: Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direct influence on the elicited response that will ensue after antigen uptake. Different approaches using antibodies, natural or synthetic ligands, fused proteins, and DNA vaccines have been explored in various veterina… Show more

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Cited by 4 publications
(4 citation statements)
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References 182 publications
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“…These cells play a pivotal role in capturing and processing antigens, subsequently presenting them to T cells to initiate specific immune responses [143,144]. Notably, among APCs, DCs exhibit the most robust antigen-presenting capabilities [145]. Extensive research has elucidated the regulatory influence of DCs on the differentiation of Treg and Th17 [146][147][148][149][150].…”
Section: Induction Of Il-17-producing Treg Differentiation By Differe...mentioning
confidence: 99%
“…These cells play a pivotal role in capturing and processing antigens, subsequently presenting them to T cells to initiate specific immune responses [143,144]. Notably, among APCs, DCs exhibit the most robust antigen-presenting capabilities [145]. Extensive research has elucidated the regulatory influence of DCs on the differentiation of Treg and Th17 [146][147][148][149][150].…”
Section: Induction Of Il-17-producing Treg Differentiation By Differe...mentioning
confidence: 99%
“…Over the past 20 years, antigen targeting tactics have been extensively investigated as preventive and therapeutic measures for infectious illnesses, autoimmunity, and cancer. These strategies have been created to improve vaccine efficiency through this mechanism of antigen capture [87]. Antigen presentation on the surface of NPs resembles the natural manner in which viruses present antigen and by managing and delaying the antigen's release, NPs can regulate the immune system's exposure to it.…”
Section: Targeting Antigen-presenting Cellsmentioning
confidence: 99%
“…“Microfold” or M cells, specialized cells with a key role in mucosal response induction in the GALT and the generation of IgA responses ( 14 ), have not been thoroughly characterized in dogs. Given their role in the GALT, various strategies have been developed for targeting these cells for mucosal vaccination, in both humans ( 15 ) and veterinary medicine ( 16 ). Vaccination with a molecule targeting M cells in mice, but not guinea pigs, has been shown to improve IgA and cellular responses in mice ( 16 ).…”
Section: Introductionmentioning
confidence: 99%
“…Given their role in the GALT, various strategies have been developed for targeting these cells for mucosal vaccination, in both humans ( 15 ) and veterinary medicine ( 16 ). Vaccination with a molecule targeting M cells in mice, but not guinea pigs, has been shown to improve IgA and cellular responses in mice ( 16 ). However, the presence and frequency of these cells in dogs will need to be evaluated to determine the feasibility of this strategy in this species.…”
Section: Introductionmentioning
confidence: 99%