Recent advances in antibiotic resistance diagnosis using SERS: focus on the “<i>Big 5</i>” challenges

Hassanain, Waleed A.; Johnson, Christopher L.; Faulds, Karen; Graham, Duncan; Keegan, Neil

doi:10.1039/d2an00703g

Cited by 18 publications

(13 citation statements)

References 145 publications

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“…The information obtained on the adsorption on metal nanoparticles, on the chemical species linked to metal, on the molecular sites directly involved in the chemical interaction, and on the structural and electronic modifications of the adsorbed molecule are of fundamental importance in view of the present and future applications of this spectroscopic technique. In this respect, the most recent SERS investigations in the field of medical diagnosis are of particular relevance [ 65 , 66 , 67 , 68 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Can DFT Calculations Provide Useful Information for SERS Applications?

Muniz‐Miranda

Menziani

et al. 2023

Molecules

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Density functional theory (DFT) calculations allow us to reproduce the SERS (surface-enhanced Raman scattering) spectra of molecules adsorbed on nanostructured metal surfaces and extract the most information this spectroscopy is potentially able to provide. The latter point mainly concerns the anchoring mechanism and the bond strength between molecule and metal as well as the structural and electronic modifications of the adsorbed molecule. These findings are of fundamental importance for the application of this spectroscopic technique. This review presents and discusses some SERS–DFT studies carried out in Italy as a collaboration between the universities of Modena and Reggio-Emilia and of Florence, giving an overview of the information that we can extract with a combination of experimental SERS spectra and DFT modeling. In addition, a selection of the most recent studies and advancements on the DFT approach to SERS spectroscopy is reported with commentary.

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Section: Discussionmentioning

confidence: 99%

Can DFT Calculations Provide Useful Information for SERS Applications?

Muniz‐Miranda

Menziani

et al. 2023

Molecules

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“…Alternatively, mobile-phone-based 144 readers, standalone readers 15 and optics integrated into the test cassette 68,145 have been explored. Surface-enhanced Raman scattering (also requiring a reader) may enable sensitive readout [146][147][148] , and separate detection of specific and non-specific binding 149 (Fig. 5c).…”

Section: Materials and Sensorsmentioning

confidence: 99%

Lateral flow test engineering and lessons learned from COVID-19

et al. 2023

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The acceptability and feasibility of large-scale testing with lateral flow tests (LFTs) for clinical and public health purposes has been demonstrated during the COVID-19 pandemic. LFTs can detect analytes in a variety of samples, providing a rapid read-out, which allows selftesting and decentralized diagnosis. In this Review, we examine the changing LFT landscape with a focus on lessons learned from COVID-19. We discuss the implications of LFTs for decentralized testing of infectious diseases, including diseases of epidemic potential, the 'silent pandemic' of antimicrobial resistance, and other acute and chronic infections. Bioengineering approaches will play a key part in increasing the sensitivity and specificity of LFTs, improving sample preparation, incorporating nucleic acid amplification and detection, and enabling multiplexing, digital connection and green manufacturing, with the aim of creating the next generation of high-accuracy, easy-to-use, affordable and digitally connected LFTs. We conclude with recommendations, including the building of a global network of LFT research and development hubs to facilitate and strengthen future diagnostic resilience. Sections• Bioengineering approaches, such as the use of nano-and quantum materials, nucleic-acid-based LFTs, CRISPR and machine learning, will improve the sensitivity, specificity, multiplexing and connectivity features of LFTs.• We recommend investing in an international LFT research and development hub network to spearhead the development of a pipeline of innovative bioengineering approaches to design next-generation LFTs.

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“…In the following sections, we will explore how the challenges herein outlined have been tackled by the SERS community, providing examples of relevant literature from the past six years (2017-2022). While there is a broad range of recent reviews on SERS, 64,65 especially on substrates [66][67][68][69][70] and biomedical applications, [71][72][73][74][75][76][77][78] we intend to offer a different take on the matter and focus on aspects that are seldom discussed, although within popular topics such as anisotropic growth. An example of these are surface chemistry and its relationship with crystal growth, monodispersity, and nal SERS performance, as well as the insights coming from computational chemistry, which aid in the elucidation of mechanisms that are still experimentally elusive.…”

Section: Overview Of Challengesmentioning

confidence: 99%